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ICTP in Bone Metastases of Lung Cancer

Franjević, Ana; Pavićević, Radomir; Bubanović, Gordana
ICTP in Bone Metastases of Lung Cancer // Collegium antropologicum, 35 (2011), 1; 43-47 (međunarodna recenzija, članak, znanstveni)

ICTP in Bone Metastases of Lung Cancer

Franjević, Ana ; Pavićević, Radomir ; Bubanović, Gordana

Collegium antropologicum (0350-6134) 35 (2011), 1; 43-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bone matrix; lung neoplasms; osteoclasts; osteolysis

Bone metastases often appear in advanced stages of lung cancer. They are the result of modulation of bone metabolism by tumor cells that migrated into bone microenvironment and degraded bone organic matrix. Measurement of C-terminal telopeptide of type I collagen (ICTP) in the serum of subjects with lung cancer with and without bone metastases and healthy population is the way to explore bone resorption. In 343 subjects included in this research ICTP level was significantly higher in the bone metastasis than other two groups. The existence of pathologic fracture significantly increased ICTP level. ICTP showed sensitivity of 66.0% in bone metastases at 95.0% specificity in lung cancer stages IA and IB. ICTP is a good diagnostic marker in detection of bone metastasis of lung cancer. Its level can distinguish lung cancer with and without bone involvement and can be used as an addition to standard techniques used in diagnostics of bone metastasis.

Izvorni jezik

Znanstvena područja
Biologija, Kliničke medicinske znanosti


Klinički bolnički centar Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus