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Pregled bibliografske jedinice broj: 512961

Targeting p73 - a potential approach in cancer treatment


Slade, Neda; Horvat, Anđela
Targeting p73 - a potential approach in cancer treatment // Current pharmaceutical design, 17 (2011), 6; 591-602 doi:10.2174/138161211795222621 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Targeting p73 - a potential approach in cancer treatment

Autori
Slade, Neda ; Horvat, Anđela

Izvornik
Current pharmaceutical design (1381-6128) 17 (2011), 6; 591-602

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
p73 ; apoptosis ; cancer ; chemosensitivity ; cancer therapy

Sažetak
The p53 family consists of three members: p53, p63 and p73. All three of them have a role in cell cycle arrest and induction of apoptosis. However, despite structural and partly functional similarity, there are striking differences in their functions and each of them has its own and unique identity. All three genes encode multiple variants with opposing functions in cancer development – full length transactivation forms with proapoptotic and antiproliferative functions, and dominant-negative transactivation-deficient forms with antiapoptotic (oncogenic) functions. The functional interactions between family members are crucial to gain insight and understand their role in cancer biology. The discovery of p53/p73 network could have a major clinical impact in prognostic use and targeted drug design. In the current review we present the recent achievements in p73 research including very complex and sophisticated p73 regulation and response to DNA damage, and functional interactions among family members. We discuss how p73 has affected drug discovery. According to the p73 tumor suppressor function, we outline current aspects of anticancer therapy.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2391 - Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka (Slade, Neda, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Neda Slade (autor)

Avatar Url Anđela Horvat (autor)

Citiraj ovu publikaciju

Slade, Neda; Horvat, Anđela
Targeting p73 - a potential approach in cancer treatment // Current pharmaceutical design, 17 (2011), 6; 591-602 doi:10.2174/138161211795222621 (međunarodna recenzija, pregledni rad, znanstveni)
Slade, N. & Horvat, A. (2011) Targeting p73 - a potential approach in cancer treatment. Current pharmaceutical design, 17 (6), 591-602 doi:10.2174/138161211795222621.
@article{article, year = {2011}, pages = {591-602}, DOI = {10.2174/138161211795222621}, keywords = {p73, apoptosis, cancer, chemosensitivity, cancer therapy}, journal = {Current pharmaceutical design}, doi = {10.2174/138161211795222621}, volume = {17}, number = {6}, issn = {1381-6128}, title = {Targeting p73 - a potential approach in cancer treatment}, keyword = {p73, apoptosis, cancer, chemosensitivity, cancer therapy} }
@article{article, year = {2011}, pages = {591-602}, DOI = {10.2174/138161211795222621}, keywords = {p73, apoptosis, cancer, chemosensitivity, cancer therapy}, journal = {Current pharmaceutical design}, doi = {10.2174/138161211795222621}, volume = {17}, number = {6}, issn = {1381-6128}, title = {Targeting p73 - a potential approach in cancer treatment}, keyword = {p73, apoptosis, cancer, chemosensitivity, cancer therapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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