engleski

MAP Kinase Signaling Pathway : A Potential Biomarker of Environmental Pollution in the Mussel Mytilus galloprovincialis

In the present study, the effects of environmental pollutants have been investigated in the Mediterranean mussel Mytilus galloprovincialis as sentinel species. For the purpose of detecting water contamination in the early stages, biomarkers of effect and exposure must be studied. Most specifically, proteins of intracellular signaling pathways appear to be very interesting targets as their conservation through evolution is maintained and since their modulation via environmental relevant levels of chemical contaminants is an indicating sign of stress for bivalves. Genes encoding the Mitogen-Activated Protein Kinases (MAPKs) in M. galloprovicialis confirmed high homology with those of other vertebrates and invertebrates. Further, mussels were exposed to various model agents: tributyltin, hydrogen peroxide and water soluble fraction of diesel fuel and the activation/phosphorylation of the MAPKs p38, JNK and ERK were evaluated by a new developed ELISA assay.

MAPKs, p38, JNK and ERK

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