Naslov
Lack of association of vitamin D receptor gene 3'- haplotypes with psoriasis in Croatian patients

Autori
Ručević, Ivana ; Štefanić, Mario ; Tokić, Stana ; Vukšić, Melita ; Glavaš-Obrovac, Ljubica ; Barišić- Druško, Vladimira

Izvornik
Journal of dermatology (0385-2407) 39 (2012), 1; 58-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Croatia; calcitriol receptors; genetic polymorphism; haplotypes; psoriasis

Sažetak
Cis-acting regulatory variants in biologically relevant pathways and target tissues are a common source of phenotypic variations and individual disease susceptibility. In the skin, vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem cell proliferation and microbial defense ; therefore, we tested whether VDR 3’-regulatory haplotypes, a portion of which affects VDR transcriptional efficiency, allelic symmetry and mRNA turnover, were associated with psoriasis vulgaris. For this purpose, three VDR tag polymorphisms that capture most of the variability of the VDR 3’-regulatory element (rs1544410, rs7975232 and rs731236) were genotyped by polymerase chain reaction-restriction fragment length polymorphism method in 180 Caucasian patients with chronic plaque psoriasis and 366 ethnically matched, healthy controls of the Croatian origin. We found no evidence of association for any of the selected polymorphisms. Similarly, none of the 3'-VDR restriction haplotypes was associated with the risk for development of psoriasis in Croatian patients. These results show that neither VDR 3’-restriction polymorphisms nor common 3’-regulatory haplotypes contribute to psoriasis risk in the Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

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