Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Interleukins IL-33 and IL-17/IL-17A in patients with ulcerative colitis (CROSBI ID 171275)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ajduković, Jasna ; Tonkić, Ante ; Salamunić, Ilza ; Hozo, Izet ; Šimunić, Miroslav ; Bonacin, Damir Interleukins IL-33 and IL-17/IL-17A in patients with ulcerative colitis // Hepato-gastroenterology, 57 (2010), 104; 1442-1444

Podaci o odgovornosti

Ajduković, Jasna ; Tonkić, Ante ; Salamunić, Ilza ; Hozo, Izet ; Šimunić, Miroslav ; Bonacin, Damir

engleski

Interleukins IL-33 and IL-17/IL-17A in patients with ulcerative colitis

Background/Aims: Disturbance of immune homeostasis in ulcerative colitis (UC) is related to the predominance of T-helper-2 (Th2) immune response. Interleukin (IL)-33 simulates Th lymphocytes to produce Th2 cytokines, such as IL-4, IL-5, and IL-13, which are believed to induce pathological changes in the intestinal mucosa. The proinflammatory role of IL-17 in UC is still unclear. Our aim was to determine serum concentrations of IL-33 and IL-17 in patients with UC and healthy controls. Methodology. Serum concentrations of IL-33 and IL-17 were measured in 18 patients (10 men) with UC and 16 control subject (10 men) by using two-layer immunoenzyme procedure (ELISA). Results: Median serum concentrations of IL-33 in patients with UC and controls were 140 pg/ml (interquartile range (IQR), 72.5 pg/ml) and 165 pg/ml (IQR, 140.0 pg/ml), respectively, but the difference was not statistically significant (Mann-Whitney U=112, p=0.281). The median serum concentration of IL-17/IL-17A in patients with UC was significantly higher (100 pg/ml, IQR 35.75 pg/ml) than that in controls (65 pg/ml, IQR 32.25 pg/ml) (Mann-Whitney U=55, p=0.002). Conclusion: ; Serum concentration of IL-33 in patients with UC was not increased in comparison with that in controls, which is in accordance with current evidence that its primary biological effect is transcriptional rather cytokinal. Further research is needed to explain whether increased concentration of IL-17 in UC is protective or harmful and to elucidate its immunological and pathogenic role.

interleukins IL-33 ; Il-17/17A ; ulcerative colitis

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

57 (104)

2010.

1442-1444

objavljeno

0172-6390

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost