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Pregled bibliografske jedinice broj: 510132

Inflammatory markers in childhood asthma


Dodig, Slavica; Richter, Darko; Zrinski Topić, Renata
Inflammatory markers in childhood asthma // Clinical chemistry and laboratory medicine, 49 (2011), 4; 587-599 doi:10.1515/CCLM.2011.094 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 510132 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inflammatory markers in childhood asthma

Autori
Dodig, Slavica ; Richter, Darko ; Zrinski Topić, Renata

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 49 (2011), 4; 587-599

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
airway inflammation; asthma; child; exhaled breath; exhaled breath condensate

Sažetak
The major characteristic of asthma is persistent airway inflammation that fails to resolve spontaneously. Dysregulation of pro- and anti-inflammatory mechanisms is responsible for the development of chronic inflammation. The inflammatory reaction is mediated by numerous cells and their mediators. Detection and quantification of airway inflammation in children are subject to many requirements, e.g., use of biologic samples obtained in a non-invasive way ; use of standardized analytical methods to determine biomarkers that can identify inflammation processes (inflammation itself, oxidative stress, apoptosis and remodelling) ; determining the role of systemic inflammation ; assessment of correlation of various biomarkers of inflammation with clinical parameters and their diagnostic efficacy ; providing a tool(s) to monitor diseases, and to evaluate adequacy of therapy ; and predicting the clinical course of inflammation and prognosis of asthma. Using standardized analyses, it is now possible to determine direct markers of local inflammation, i.e., fractional nitric oxide (marker of oxidative stress) in exhaled breath, pH (marker of acid stress) in breath condensate, and indirect markers in blood/serum, i.e., eosinophil granulocytes (indicating migration), eosinophil cationic protein (marker of activated eosinophil granulocytes) and C-reactive protein (marker of systemic inflammation). However, none of these biomarkers are specific for asthma. Further standardization of the known pulmonary biomarkers of local inflammation and identification of new ones will allow for longitudinal follow-up of inflammation in children with asthma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
277-2770966-0965 - Kondenzat izdaha kao izvor biomarkera plućnih bolesti u djece (Dodig, Slavica, MZOS ) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Dječja bolnica Srebrnjak

Profili:

Avatar Url Slavica Dodig (autor)

Avatar Url Darko Richter (autor)

Avatar Url Renata Zrinski Topić (autor)

Citiraj ovu publikaciju

Dodig, Slavica; Richter, Darko; Zrinski Topić, Renata
Inflammatory markers in childhood asthma // Clinical chemistry and laboratory medicine, 49 (2011), 4; 587-599 doi:10.1515/CCLM.2011.094 (međunarodna recenzija, pregledni rad, znanstveni)
Dodig, S., Richter, D. & Zrinski Topić, R. (2011) Inflammatory markers in childhood asthma. Clinical chemistry and laboratory medicine, 49 (4), 587-599 doi:10.1515/CCLM.2011.094.
@article{article, year = {2011}, pages = {587-599}, DOI = {10.1515/CCLM.2011.094}, keywords = {airway inflammation, asthma, child, exhaled breath, exhaled breath condensate}, journal = {Clinical chemistry and laboratory medicine}, doi = {10.1515/CCLM.2011.094}, volume = {49}, number = {4}, issn = {1434-6621}, title = {Inflammatory markers in childhood asthma}, keyword = {airway inflammation, asthma, child, exhaled breath, exhaled breath condensate} }
@article{article, year = {2011}, pages = {587-599}, DOI = {10.1515/CCLM.2011.094}, keywords = {airway inflammation, asthma, child, exhaled breath, exhaled breath condensate}, journal = {Clinical chemistry and laboratory medicine}, doi = {10.1515/CCLM.2011.094}, volume = {49}, number = {4}, issn = {1434-6621}, title = {Inflammatory markers in childhood asthma}, keyword = {airway inflammation, asthma, child, exhaled breath, exhaled breath condensate} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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