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Pregled bibliografske jedinice broj: 509993

Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells


Helbig, Lars; Damrot, Julia; Johannes Hülsenbeck; Köberle, Beate; Brozović, Anamaria; Osmak, Maja; Fiket, Željka; Kaina, Bernd; Fritz, Gerhard
Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells // The Journal of biological chemistry, 286 (2011), 15; 12991-13001 doi:10.1074/jbc.M110.190645 (međunarodna recenzija, članak, znanstveni)


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Naslov
Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells

Autori
Helbig, Lars ; Damrot, Julia ; Johannes Hülsenbeck ; Köberle, Beate ; Brozović, Anamaria ; Osmak, Maja ; Fiket, Željka ; Kaina, Bernd ; Fritz, Gerhard

Izvornik
The Journal of biological chemistry (0021-9258) 286 (2011), 15; 12991-13001

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA damage response; DNA repair; cisplatin-DNA adducts; SAPK/JNK

Sažetak
Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by activation of Ataxia telangiectasia mutated- and Rad3-related kinase, replication protein A, and checkpoint kinases as well as by the formation of DNA double strand breaks (DSBs). Ionizing radiation-induced DSBs did not provoke SAPK/JNK activation, and inhibition of transcription also failed to provoke this response. Late activation of SAPK/JNK stimulated by cisplatin-induced DNA lesions was reduced in the absence of specific DNA repair proteins, such as xeroderma pigmentosum protein C, pointing to an essential function of individual repair factors in DNA damage signaling to SAPK/JNK. Collectively, the data indicate that late SAPK/JNK activation is triggered by non-repaired cisplatin adducts in transcribed genes and involves replication-associated events, DSBs, tyrosine kinases, Rho GTPases, and specific repair factors.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Maja Osmak, )
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Andreja Ambriović Ristov, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Osmak (autor)

Avatar Url Anamaria Brozović (autor)

Avatar Url Željka Fiket (autor)

Citiraj ovu publikaciju

Helbig, Lars; Damrot, Julia; Johannes Hülsenbeck; Köberle, Beate; Brozović, Anamaria; Osmak, Maja; Fiket, Željka; Kaina, Bernd; Fritz, Gerhard
Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells // The Journal of biological chemistry, 286 (2011), 15; 12991-13001 doi:10.1074/jbc.M110.190645 (međunarodna recenzija, članak, znanstveni)
Helbig, L., Damrot, J., Johannes Hülsenbeck, Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B. & Fritz, G. (2011) Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells. The Journal of biological chemistry, 286 (15), 12991-13001 doi:10.1074/jbc.M110.190645.
@article{article, year = {2011}, pages = {12991-13001}, DOI = {10.1074/jbc.M110.190645}, keywords = {DNA damage response, DNA repair, cisplatin-DNA adducts, SAPK/JNK}, journal = {The Journal of biological chemistry}, doi = {10.1074/jbc.M110.190645}, volume = {286}, number = {15}, issn = {0021-9258}, title = {Late activation of stress-activated protein kinases/C-JUN-N- terminal kinases triggered by cisplatin-induced DNA damage repair defective cells}, keyword = {DNA damage response, DNA repair, cisplatin-DNA adducts, SAPK/JNK} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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