Impact of early steroid withdrawal (ESW) on progression of chronic biopsy scores after kidney transplantation (CROSBI ID 572078)
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Podaci o odgovornosti
Mihovilović, Karlo ; Bacalja, Jasna ; Galešić Ljubanović, Danica ; Kovačević-Vojtušek, Ivana ; Gracin, Sonja ; Gustin, Denis ; Vidas, Željko ; Sabljar-Matovinović, Mirjana ; Knotek, Mladen
engleski
Impact of early steroid withdrawal (ESW) on progression of chronic biopsy scores after kidney transplantation
Long-term effects of ESW on development of chronic pathohistology changes in kidney allograft is unclear. In this study we compared chronic scores on protocol biopsies in Caucasian kidney recipients(N=41) without DGF with ESW vs. continuous steroids on top of CNI and MMF. Induction consisted of IL-2RA or ATG. Protocol biopsies were done on day 0 and 1 year afer transplant. Chronic scores (ci, ct, cg, mm, cv and ah) were analyzed by Banff' 97 classification. ESW was not associated with changes in ci, ct, cg, mm and cv scores, but slight progression of ah score was noticed in ESW group(0.49±0.51 vs. 0.21±0.41 ; p=0.02). In multivariate analysis including recipient age and gender, donor age, type of donation (living or deceased) and type of transplant (kidney or kidney/pancreas), ESW was independently associated with progression of ah score (p=0.049). In conclusion, ESW may cause progression of ah score during first 12 months postransplant, without impact on other chronic scores.
early steroid withdrawal; chronic scores; kidney transplantation
doi:10.1053/j.ajkd.2011.02.209
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Podaci o prilogu
B68-B68.
2011.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
American journal of kidney diseases
0272-6386
Podaci o skupu
Nationa Kidney Foundation 2011 Spring Clinical Meetings
poster
26.04.2011-01.05.2011
Las Vegas (NV), Sjedinjene Američke Države
Povezanost rada
Kliničke medicinske znanosti