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Pregled bibliografske jedinice broj: 509150

The TP53 gene polymorphisms and survival of sporadic breast cancer patients


Bišof, Vesna; Peričić Salihović, Marijana; Smolej Narančić, Nina; Škarić-Jurić, Tatjana; Jakić-Razumović, Jasminka; Janićijević, Branka; Rudan, Pavao
The TP53 gene polymorphisms and survival of sporadic breast cancer patients // Medical oncology, 29 (2012), 2; 472-478 doi:10.1007/s12032-011-9875-2 (međunarodna recenzija, članak, znanstveni)


Naslov
The TP53 gene polymorphisms and survival of sporadic breast cancer patients

Autori
Bišof, Vesna ; Peričić Salihović, Marijana ; Smolej Narančić, Nina ; Škarić-Jurić, Tatjana ; Jakić-Razumović, Jasminka ; Janićijević, Branka ; Rudan, Pavao

Izvornik
Medical oncology (1357-0560) 29 (2012), 2; 472-478

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Breast cancer; survival; polymorphisms; TP53 gene; chemotherapy

Sažetak
The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in different cancers including breast cancer. The aim of the present study is to investigate a potential association between different genotypes of these polymorphisms and clinicopathological variables with survival of breast cancer patients in Croatian population. Ninety-four women with sporadic breast cancer were retrospectively analyzed. Median follow-up period was 67.9 months. The effects of basic clinical and histopathological characteristics of tumor on survival were tested by Cox's proportional hazards regression analysis. The TNM stage was associated with overall survival by Kaplan-Meier analysis, univariate, and multivariate Cox's proportional hazards regression analysis, while grade was associated with survival by Kaplan-Meier analysis and univariate Cox's proportional hazards regression analysis. Different genotypes of the Arg72Pro and PIN3 (+16 bp) polymorphisms had no significant impact on survival in breast cancer patients. However, in subgroup of patients treated with chemotherapy without anthracycline, the A2A2 genotype of the PIN3 (+16 bp) polymorphism was associated with poorer overall survival than other genotypes by Kaplan-Meier analysis (P = 0.048). The TP53 polymorphisms, Arg72Pro and PIN3 (+16 bp), had no impact on survival in unselected sporadic breast cancer patients in Croatian population. However, the results support the role of the A2A2 genotype of the PIN3 (+16 bp) polymorphism as a marker for identification of patients that may benefit from anthracycline-containing chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA


Projekt / tema
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Pavao Rudan, )
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Branka Janićijević, )

Ustanove
Institut za antropologiju,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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