engleski

Tumor suppressor gene Axin 1.Atlas Genet Cytogenet Oncol Haematol. May 2011

Tumor suppressor gene Axin 1 is an inhibitor of the Wnt signaling pathway. It down-regulates beta-catenin, wnt pathway's main effector signaling molecule, by facilitating its phosphorylation by GSK3-beta. It binds directly to APC (adenomatous polyposis coli), beta-catenin, GSK3-beta and dishevelled forming a so called “beta-catenin destruction complex” in which phosphorylated beta-catenin is targeted for quick ubiquitinilation and degradation in the 26S proteosome. In response to wnt signaling, or under the circumstances of mutated axin or APC, beta-catenin is stabilized, accumulates in the cytoplasm and enters the nucleus, where it finds a partner, a member of the DNA binding protein family LEF/TCF. Together they stimulate the expression of target genes including c-myc, c-jun, fra-1 and cyclin D1.

AXIN-1; AXIN; hAXIN; MGC52315; Axis inhibitor 1

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