engleski

Palladium(II) and platinum(II) complexes of diethyl 8-nitroquinolin-2-ylmethylphosphonate

The study of aminophosphonic acids and their esters is of current interest owing to their diverse biological properties and numerous applications in the medicinal and agrochemical fields. Another interesting aspect regarding this class of compounds arises from their ability of forming different types of metal complexes that might be also of interest as potential biologically active compounds. Thus, some aminophosphonate complexes of platinum group metals have been found cytotoxic against animal and human tumor cell lines. Continuing our research in this area, the synthesis, some spectroscopic, thermal and biological properties of diethyl 8-nitroquinolin-2-ylmethylphosphonate and its palladium(II) and platinum(II) dihalide complexes, have been reported. The results obtained were compared with those previously reported for diethyl quinolinylmethylphosphonates and their palladium(II) and platinum(II) complexes, and discussed with respect to their metal-binding behaviour and structure-activity relationship.

quinolinylmethylphosphonate; palladium complex; platinum complex; synthesis

nije evidentirano