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Pregled bibliografske jedinice broj: 508628

Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia


Bosnar, Martina; Čužić, Snježana; Bošnjak, Berislav; Nujić, Krunoslav; Ergović, Gabrijela; Marjanović, Nikola; Pašalić, Ivanka; Hrvačić, Boška; Polančec, Denis; Glojnarić, Ines; Eraković Haber, Vesna
Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia // International immunopharmacology, 11 (2011), 4; 424-434 doi:10.1016/j.intimp.2010.12.010 (međunarodna recenzija, članak, znanstveni)


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Naslov
Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia

Autori
Bosnar, Martina ; Čužić, Snježana ; Bošnjak, Berislav ; Nujić, Krunoslav ; Ergović, Gabrijela ; Marjanović, Nikola ; Pašalić, Ivanka ; Hrvačić, Boška ; Polančec, Denis ; Glojnarić, Ines ; Eraković Haber, Vesna

Izvornik
International immunopharmacology (1567-5769) 11 (2011), 4; 424-434

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
activator protein-1; azithromycin; interleukin-1β; lipopolysaccharide-induced pulmonary neutrophilia

Sažetak
Macrolide antibiotics, including azithromycin, also possess anti-inflammatory properties. However, the molecular mechanism(s) of activity as well as the target cells for their action have not been unambiguously identified as yet. In this study, the effects of azithromycin on lipopolysaccharide (LPS)-induced pulmonary neutrophilia were investigated in mice. Using immunohistochemistry, mRNA and specific protein assays, we confirmed that azithromycin ameliorates LPS-induced pulmonary neutrophilia by inhibiting interleukin-1β (IL-1β) expression and production selectively in alveolar macrophages as well as in LPS-stimulated J774.2 macrophage-derived cells in vitro. Inhibition by azithromycin of neutrophilia and IL-1β was accompanied by prevention of nuclear expression of activator protein-1 (AP-1) in both alveolar macrophages and J774.2 cells. The macrolide did not alter nuclear factor kappa B (NF-κB) or extracellular signal-regulated kinase 1/2 (ERK1/ 2) expression, activation or localization in LPS-stimulated lungs or in J774.2 cells. In conclusion, we have shown that inhibition of LPS-induced pulmonary neutrophilia and IL-1β concentrations in lung tissue following azithromycin treatment is mediated through effects on alveolar macrophages. In addition, we have shown for the first time, in an in vivo model, that azithromycin inhibits AP-1 activation in alveolar macrophages, an action confirmed on J774.2 cells in vitro.

Izvorni jezik
Engleski



POVEZANOST RADA


Citiraj ovu publikaciju

Bosnar, Martina; Čužić, Snježana; Bošnjak, Berislav; Nujić, Krunoslav; Ergović, Gabrijela; Marjanović, Nikola; Pašalić, Ivanka; Hrvačić, Boška; Polančec, Denis; Glojnarić, Ines; Eraković Haber, Vesna
Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia // International immunopharmacology, 11 (2011), 4; 424-434 doi:10.1016/j.intimp.2010.12.010 (međunarodna recenzija, članak, znanstveni)
Bosnar, M., Čužić, S., Bošnjak, B., Nujić, K., Ergović, G., Marjanović, N., Pašalić, I., Hrvačić, B., Polančec, D., Glojnarić, I. & Eraković Haber, V. (2011) Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia. International immunopharmacology, 11 (4), 424-434 doi:10.1016/j.intimp.2010.12.010.
@article{article, year = {2011}, pages = {424-434}, DOI = {10.1016/j.intimp.2010.12.010}, keywords = {activator protein-1, azithromycin, interleukin-1β, lipopolysaccharide-induced pulmonary neutrophilia}, journal = {International immunopharmacology}, doi = {10.1016/j.intimp.2010.12.010}, volume = {11}, number = {4}, issn = {1567-5769}, title = {Azithromycin inhibits macrophage interleukin-1β production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia}, keyword = {activator protein-1, azithromycin, interleukin-1β, lipopolysaccharide-induced pulmonary neutrophilia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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