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Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies


Hranjec, Marijana; Lučić, Borka; Ratkaj, Ivana; Kraljević Pavelić, Sandra; Piantanida, Ivo; Pavelić, Krešimir; Karminski-Zamola, Grace
Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies // European journal of medicinal chemistry, 46 (2011), 7; 2748-2758 doi:10.1016/j.ejmech.2011.03.062 (međunarodna recenzija, članak, znanstveni)


Naslov
Novel Imidazo[4, 5-b]Pyridine and Triaza-Benzo[c]Fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies

Autori
Hranjec, Marijana ; Lučić, Borka ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Piantanida, Ivo ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 46 (2011), 7; 2748-2758

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Imidazo[4 ; 5-b]pyridines ; triaza-benzo[c]fluorenes ; antiproliferative activity ; interaction with ctDNA ; apoptosis ; cell cycle

Sažetak
In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes (7-21, 24-26, 28-29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lines in a dose-dependent manner. In particular, imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes including 2-imidazolinyl derivatives showed the most potent antitumour activity. Similarly, triaza-benzo[c]fluorenes 18 and 20 induced strong growth inhibition of tested tumour cell lines, and showed low cytotoxicity in normal human fibroblasts. DNA interaction studies of these compounds demonstrated that N-methylated 16 and 2-imidazolinyl 28 triaza-benzo[c]fluorenes bind to DNA in an intercalative mode.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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