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Pregled bibliografske jedinice broj: 508005

Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression


Sobočanec, Sandra; Balog, Tihomir; Šariċ, Ana; Mačak-Šafranko, Željka; Štroser, Marina; Žarković, Kamelija; Žarković, Neven; Stojković, Ranko; Ivanković, Siniša; Marotti, Tatjana
Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression // Phytomedicine, 18 (2011), 852-858 doi:10.1016/j.phymed.2011.01.015 (međunarodna recenzija, članak, znanstveni)


Naslov
Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression

Autori
Sobočanec, Sandra ; Balog, Tihomir ; Šariċ, Ana ; Mačak-Šafranko, Željka ; Štroser, Marina ; Žarković, Kamelija ; Žarković, Neven ; Stojković, Ranko ; Ivanković, Siniša ; Marotti, Tatjana

Izvornik
Phytomedicine (0944-7113) 18 (2011); 852-858

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Propolis ; mammary carcinoma ; DPD ; tumor growth ; metastasis ; gender-related

Sažetak
The aim of this study was to detect the antitumor properties of Croatian propolis in BALB/c male and female mice injected with 4T1 mammary carcinoma. Furthermore, the gender- dependence of this effect and the possible involvement of combined effect of propolis and 5-Fluorouracil (5FU) on dihydropyrimidine dehydrogenase (DPD) transcriptional and translational level, were determined. In combination with 5FU propolis treatment induced gender-related effects. The results of the study revealed that pretreatment of mice with propolis combined with 5FU treatment prolonged the suppressive effect of 5FU on tumor growth and reduced the number of metastasis only in male mice. Only males pretreated with propolis prior to 5FU administration had decreased DPD protein level indicating higher sensitivity to 5FU. Thus, benefitial effects of propolis in male tumor-bearing mice treated with 5FU might be explained by increased sensitivity to 5FU as the result of translationally downregulated DPD.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekt / tema
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Tihomir Balog, )
098-0982464-2390 - Novi terapijski modaliteti u liječenju malignih bolesti (Ranko Stojković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)


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