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Pregled bibliografske jedinice broj: 507978

A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation


Bidwell, Gene Lee III.; Whittom, Angela; Thomas, Emily; Lyons, Daniel; Hebert, Michael; Raucher, Dražen
A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation // Peptides, 31 (2010), 5; 834-841 doi:10.1016/j.peptides.2010.02.007 (međunarodna recenzija, članak, znanstveni)


Naslov
A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation

Autori
Bidwell, Gene Lee III. ; Whittom, Angela ; Thomas, Emily ; Lyons, Daniel ; Hebert, Michael ; Raucher, Dražen

Izvornik
Peptides (0196-9781) 31 (2010), 5; 834-841

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Drug delivery; thermal targeting; cell cycle inhibition

Sažetak
Targeting splicing machinery components is an underdeveloped strategy for cancer therapy. Uridine-rich small nuclear ribonucleoproteins (UsnRNPs) are essential spliceosome components that recognize splice sites in newly transcribed RNA. The major spliceosomal snRNPs are comprised of UsnRNA bound by a ring of Sm proteins. The survival of motor neuron (SMN) complex provides specificity for binding of Sm proteins to UsnRNAs. Three of the seven proteins that comprise the Sm core possess post-translationally modified C-terminal symmetric dimethylarginine (sDMA) residues which promote binding of these proteins to SMN. Here we describe a peptide inhibitor of sDMA that is capable of interfering with SMN/SmB interaction. The inhibitory peptide was attached to elastin-like polypeptide, a thermally responsive macromolecular carrier, in order to increase its stability and allow enhancement of its cellular uptake by thermal targeting. The fusion polypeptide inhibited the interaction of SMN/SmB, inhibited proliferation, and induced apoptosis in HeLa cells

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-0000000-3364 - Ciljano toplinsko dopremanje lijekova u solidne tumore (Dražen Raucher, )

Ustanove
Medicinski fakultet, Osijek

Autor s matičnim brojem:
Dražen Raucher, (280455)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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