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Pregled bibliografske jedinice broj: 507915

Cell penetrating elastin-like polypeptides for therapeutic peptide delivery

Bidwell, Gene Lee III.; Raucher, Dražen
Cell penetrating elastin-like polypeptides for therapeutic peptide delivery // Advanced drugs delivery reviews, 62 (2010), 15; 1486-1496 doi:10.1016/j.addr.2010.05.003 (međunarodna recenzija, pregledni rad, znanstveni)

Cell penetrating elastin-like polypeptides for therapeutic peptide delivery

Bidwell, Gene Lee III. ; Raucher, Dražen

Advanced drugs delivery reviews (0169-409X) 62 (2010), 15; 1486-1496

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Drug delivery; thermal targeting; cell-penetrating peptide

Current treatment of solid tumors is limited by side effects that result from the non-specific delivery of drugs to the tumor site. Alternative targeted therapeutic approaches for localized tumors would significantly reduce systemic toxicity. Peptide therapeutics are a promising new strategy for targeted cancer therapy because of the ease of peptide design and the specificity of peptides for their intracellular molecular targets. However, the utility of peptides is limited by their poor pharmacokinetic parameters and poor tissue and cellular membrane permeability in vivo. This review article summarizes the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutic peptides (TP), and the use of cell penetrating peptides (CPP) to enhance the intracellular delivery of the ELP-fused TPs. CPP-fused ELPs have been used to deliver a peptide inhibitor of c-Myc function and a peptide mimetic of p21 in several cancer models in vitro, and both polypeptides are currently yielding promising results in in vivo models of breast and brain cancer.

Izvorni jezik

Znanstvena područja
Biologija, Temeljne medicinske znanosti


Projekt / tema
219-0000000-3364 - Ciljano toplinsko dopremanje lijekova u solidne tumore (Dražen Raucher, )

Medicinski fakultet, Osijek

Autor s matičnim brojem:
Dražen Raucher, (280455)

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus