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Pregled bibliografske jedinice broj: 506239

Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction


Kukoč-Modun, Lea; Plazibat, Ivana; Radić, Njegomir
Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction // Croatica chemica acta, 84 (2011), 1; 81-85 doi:10.5562/cca1753 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 506239 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction

Autori
Kukoč-Modun, Lea ; Plazibat, Ivana ; Radić, Njegomir

Izvornik
Croatica chemica acta (0011-1643) 84 (2011), 1; 81-85

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-acetyl-L-cysteine ; flow injection spectrometry ; pharmaceuticals

Sažetak
A flow-injection spectrophotometric method is developed for determination of N-acetyl-L-cysteine (NAC) in pharmaceutical formulations. The method is based on coupled redox-complexation reaction, the first step of which is the reduction of FeIII by NAC ; the second one includes the complexation of FeII, resulting from the preceding redox reaction, with 2, 4, 6-tripyridyl-s-triazine (TPTZ). The stable Fe(TPTZ)22+ complex exhibits an absorption maximum at λ = 593 nm. Under experimental conditions, optimized by univariate method, a linear calibration curve is established in NAC concentration range from 6.0×10−6 mol L–1 to 2.0×10–4 mol L–1 with NAC detection limit of 2.0×10–6 mol L–1. The analytical fre-quency was 60 h–1. Usual excipients used as additives in pharmaceuticals do not interfere with the analysis of NAC. The proposed method is simple, rapid, sensitive, accurate and precise (repeatability RSD 0.29 %, n = 10), and can be applied for determination of NAC in pharmaceutical formulations up to nano- mole quantity. (doi: 10.5562/cca1753)

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
011-0000000-3217 - Određivanje tiola primjenom potenciometrijskih senzora i spektroskopije (Njegomir Radić, )
125-2120898-3148 - Hrvatsko nazivlje u analitičkoj kemiji (Marija Kaštelan-Macan, )

Ustanove
Kemijsko-tehnološki fakultet, Split,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Njegomir Radić (autor)

Avatar Url Lea Kukoč Modun (autor)

Avatar Url Ivana Panžić (autor)

Citiraj ovu publikaciju

Kukoč-Modun, Lea; Plazibat, Ivana; Radić, Njegomir
Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction // Croatica chemica acta, 84 (2011), 1; 81-85 doi:10.5562/cca1753 (međunarodna recenzija, članak, znanstveni)
Kukoč-Modun, L., Plazibat, I. & Radić, N. (2011) Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction. Croatica chemica acta, 84 (1), 81-85 doi:10.5562/cca1753.
@article{article, year = {2011}, pages = {81-85}, DOI = {10.5562/cca1753}, keywords = {N-acetyl-L-cysteine, flow injection spectrometry, pharmaceuticals}, journal = {Croatica chemica acta}, doi = {10.5562/cca1753}, volume = {84}, number = {1}, issn = {0011-1643}, title = {Flow-injection spectrophotometric determination of N-Acetyl-L-cysteine based on coupled redox-complexation reaction}, keyword = {N-acetyl-L-cysteine, flow injection spectrometry, pharmaceuticals} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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