engleski

Patients with schizophrenia and agressive behavior: treatment with combination of risperiodne and topiramat

AIM: to present results of the investigation of efficacy of combination of risperidone and topiramat in patients with schizophrenia and dominant aggressive behavior. METHODS: the research comprised 30 patients with schizophrenia according to the DSM-IV-TR diagnostic criteria. Patients were admitted in Vrapce Psychiatric Hospital because of aggressive behavior during psychotic episode in the period from May to September, 2007. The Clinical Global Impression (CGI), Positive and Negative Syndrome Scale (PANSS) were used in order to assess patients' condition. The first assessment was made prior to initiation of the treatment. Patients were assessed daily during period of one week, and following assessments were performed on weekly basis during first month of treatment. RESULTS: After one month PANSS total score significantly improved in 26 patients. The mean Clinical Global Impression severity score for 26 patients improved from markedly ill to mildly ill. Four patients did not finish the study due to side effects (tremor, sedation, weight decrease). CONCLUSION: Administration of combination of risperidone and topiramat was clinically beneficial for the patients with schizophrenia and dominant aggressive behavior.

schizophrenia; agressive behavior; treatment

nije evidentirano