Veterinary drug residues determination in raw milk in Croatia (CROSBI ID 170104)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Bilandžić, Nina ; Solomun Kolanović, Božica ; Varenina, Ivana ; Scortichini, Giampiero ; Brstilo, Mate ; Rudan, Nevenka
engleski
Veterinary drug residues determination in raw milk in Croatia
A total of 1259 raw milk samples were examined over a three-year period for various antibiotics chloramphenicol, penicillins, cephalosporines, tetracyclines, sulfonamides, beta-lactams, quinolones, aminoglycosides and macrolides. Microbiological and immunoassay methods used for determination of these antibiotics were validated according to the guidelines laid down by European Commission Decision 2002/657/EC. Microbiological screening detected 36 positive samples, of which the presence of residues was confirmed in only one violative sample. Also one additional sample using immunoassay determination was found positive on tetracycline residues. In total, 37 positive samples were determined in three-year period, which was equal to a frequency of 0.69% of the total number of targeted analyses. The HPLC-DAD method confirmed the presence of veterinary drug residues above the maximum residues levels (MRLs) established by European Union legislation in two samples with concentrations of 12 µg kg-1 for penicillin G, 19 µg kg-1 for amoxicillin, and 1671 µg kg-1 for tetracycline. Calculated estimated daily intakes (EDIs) for antibiotic presented showed lower levels than the fixed values of acceptable daily intakes (ADIs). These suggested that raw milk in Croatia contain very low levels of veterinary drugs so that toxicological risk with regard to consuming of milk could not be considered as a public health problem and that milk are safe for human consumption.
veterinary drugs; milk; estimated dietary intake
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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