Characterisation of novel porphyrin-antibody conjugates for use in photodynamic therapy of cancer (CROSBI ID 571094)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Smith, Karen A. ; Madden, Leigh A. ; Hudson, Robert ; Pesa, Nela ; Swann, Joanne ; Savoie, Huguette ; Boyle, Ross W. ; Greenman, John
engleski
Characterisation of novel porphyrin-antibody conjugates for use in photodynamic therapy of cancer
The synthesis of several three cationic 5, 15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy (PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind cancer cells that express the corresponding antigen.
Bioconjugation; Porphyrin; Monoclonal antibody; Photodynamic therapy; Cancer
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Podaci o prilogu
S64-S64.
2003.
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objavljeno
Podaci o matičnoj publikaciji
International journal of molecular medicine
Spandidos, Demetrios A.
Atena: Spandidos Publications
1107-3756
Podaci o skupu
8th World Congress on Advances in Oncology and 6th International Symposium on Molecular Medicine
poster
16.10.2003-18.10.2003
Kreta, Grčka
Povezanost rada
Kemija, Temeljne medicinske znanosti, Biologija
