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Pregled bibliografske jedinice broj: 504683

Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action


Smith, Karen; Malatesti, Nela; Cauchon, Nicole; Hunting, Darel; Lecomte, Roger; van Lier, Johan E.; Greenman, John; Boyle, Ross W.
Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action // Immunology, 132 (2011), 2; 256-265 doi:10.1111/j.1365-2567.2010.03359.x (međunarodna recenzija, članak, znanstveni)


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Naslov
Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action

Autori
Smith, Karen ; Malatesti, Nela ; Cauchon, Nicole ; Hunting, Darel ; Lecomte, Roger ; van Lier, Johan E. ; Greenman, John ; Boyle, Ross W.

Izvornik
Immunology (0019-2805) 132 (2011), 2; 256-265

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bioconjugation ; Head and neck cancer ; Monoclonal antibody ; Photodynamic therapy

Sažetak
Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize antigens commonly over-expressed on a range of tumour cells. In vitro, all conjugates retained the phototoxicity of the porphyrin and the immunoreactivity of the antibody. Mechanistic studies showed that conjugates formed from the mono- and tri-cationic porphyrin and anti-CD104 antibody mediated apoptosis following irradiation with non-thermal red light of 630 ± 15 nm wavelength. In vivo antibody conjugates caused suppression of human LoVo tumour growth in immunodeficient NIH III mice, similar to the commercial photodynamic therapy (PDT) agent Photofrin®, but at administered photosensitizer doses that were more than two orders of magnitude lower. Positron emission tomography (PET) following PDT showed a large, early increase in uptake of 18fluorodeoxyglucose (FDG) by tumours treated with the anti-CD104 conjugates. This effect was not observed with Photofrin® or with conjugates formed from the same photosensitizers conjugated to an irrelevant antibody.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Sveučilište u Osijeku - Odjel za kemiju

Profili:

Avatar Url Nela Malatesti (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Smith, Karen; Malatesti, Nela; Cauchon, Nicole; Hunting, Darel; Lecomte, Roger; van Lier, Johan E.; Greenman, John; Boyle, Ross W.
Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action // Immunology, 132 (2011), 2; 256-265 doi:10.1111/j.1365-2567.2010.03359.x (međunarodna recenzija, članak, znanstveni)
Smith, K., Malatesti, N., Cauchon, N., Hunting, D., Lecomte, R., van Lier, J., Greenman, J. & Boyle, R. (2011) Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action. Immunology, 132 (2), 256-265 doi:10.1111/j.1365-2567.2010.03359.x.
@article{article, year = {2011}, pages = {256-265}, DOI = {10.1111/j.1365-2567.2010.03359.x}, keywords = {Bioconjugation, Head and neck cancer, Monoclonal antibody, Photodynamic therapy}, journal = {Immunology}, doi = {10.1111/j.1365-2567.2010.03359.x}, volume = {132}, number = {2}, issn = {0019-2805}, title = {Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action}, keyword = {Bioconjugation, Head and neck cancer, Monoclonal antibody, Photodynamic therapy} }
@article{article, year = {2011}, pages = {256-265}, DOI = {10.1111/j.1365-2567.2010.03359.x}, keywords = {Bioconjugation, Head and neck cancer, Monoclonal antibody, Photodynamic therapy}, journal = {Immunology}, doi = {10.1111/j.1365-2567.2010.03359.x}, volume = {132}, number = {2}, issn = {0019-2805}, title = {Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action}, keyword = {Bioconjugation, Head and neck cancer, Monoclonal antibody, Photodynamic therapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • AGRICOLA
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  • BIOSIS Previews (Biological Abstracts)
  • Chemoreception Abstracts
  • EMBASE (Excerpta Medica)
  • MEDLINE
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