engleski

Malignant neuroleptic syndrome in psychopharmacotherapy of psychotic patients

In a ten-year follow-up study of 3602 psychotic patients hospitalized at the Clinical Department of Psychiatric Hospital Vrapce In Zagreb, the efficacy and tolerance of psychotropic drugs were evaluated. The average number of hospitalizations was 2.6 per patient. The authors present the structure of drugs administered in certain phases of treatment, with regard to all drugs administered simultaneously, and the nature of side effects that appeared in any phase of the treatment. A special attention was paid to diagnostic of malignant neuroleptic syndrome (MNS). It was found in 18 patients, all of whom belonged to the age group between 35 and 61 years. Before the onset of MNS in those patients, psychopharmacotherapy was applied over one week to more than a year. A tendency towards the relapse of MNS was found in some patients. In 20.2% of the subjects, clozapine was administered as monotherapy. None of them developed MNS, so the authors conclude that clozapine is a psychotropic drug of choice in the patients suspect of developing MNS.

Malignant neuroleptic syndrome; psychopharmacotherapy; psychosis

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