engleski

Synthesis of novel heterocyclic amides and their cyclic analogues

Over the past few decades, heterocyclic compounds and their biological activity are intensively investigated.[1] The constant and growing interest in the development of new efficient and general synthetic methods for the preparation of heterocyclic systems involving tiophene, benzo[b]tiophene and benzothiazole subunits is justified by their well-established valuable physiological and pharmacological properties.[2-4] In this work novel derivatives of heterocyclic amides and their cyclic analogues are synthesized. Many different methods are known to obtain amides and the method used here is the direct synthesis from acidic chlorides and corresponding amines. Their cyclic analogues were prepared by photochemical dehydrohalogenation. All compounds were characterized using 1H, 13C NMR, IR and UV/Vis spectroscopy. Literature: [1] Jarak, I. ; Kralj, M. ; Šuman, L. ; Pavlović, G. ; Dogan, J. ; Piantanida, I. ; Žinić, M. ; Pavelić, K. ; Karminski-Zamola, G. J. Med. Chem. 2005, 48, 2346-2360. [2] Jarak, I. ; Kralj, M. ; Piantanida, I. ; Šuman, L. ; Žinić, M. ; Pavelić, K. ; Karminski-Zamola, G. Bioorg. Med. Chem. 2006, 14, 2859-2868. [3] David-Cordonnier, M. ; Lemster, T. ; Pindur, U. ; Lenglet, G. ; Depauw, S. ; Dassi, C. Eur. J. Med. Chem. 2009, 44, 3235–3252. [4] Al-Obaid, A. M. ; Abdel-Hamide, S. G. ; El-Kashef, H. A. ; Abdel-Aziz, A. A.-M. ; El-Azab, A. S. ; Al-Khamees, H. A. ; El-Subbagh, H. I. Eur. Med. Chem. 2009, 44, 2379–2391.

benzothiazoles; benzo[b]thiophenes; quinolones

nije evidentirano