DNA topoisomerase I and repair of genomic damage (CROSBI ID 476092)
Prilog sa skupa u zborniku | izvorni znanstveni rad | domaća recenzija
Podaci o odgovornosti
Nagy, Biserka ; Furčić, Ivana
engleski
DNA topoisomerase I and repair of genomic damage
Recent evidence indicates that unrepaired genomic damage influences the catalytic activities of DNA topoisomerases. DNA lesions such as base mismatches, pyrimidinic dimers, 6, 4-photoproducts, apurinic and apyrimidinic sites and others, enhance topoisomerase I mediated DNA cleavage. These findings suggest that topoisomerase activity can be influenced by spontaneous, as well as environmentally induced damages to DNA. In this study the catalytic activity of topoisomerase I was examined Xeroderma pigmentosum cell lines B and C and compared with the activity of normal human cells. The data show that topoisomerase I levels are higher in two repair-deficient cell lines. This provide novel insight into the mechanism of action of topoisomerases and raise new questions regarding mechanism of topoisomerase-targeting drugs.
Xeroderma pigmentosum cells; topoisomerase I activity; DNA damage
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
15-18-x.
2000.
objavljeno
Podaci o matičnoj publikaciji
Current Studies of Biotechnology
Zlatko, Kniewald i ost.
Zagreb: Hrvatsko biotehnološko društvo
Podaci o skupu
Nepoznat skup
predavanje
29.02.1904-29.02.2096