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Pregled bibliografske jedinice broj: 50339

DNA topoisomerase I and repair of genomic damage


Nagy, Biserka; Furčić, Ivana
DNA topoisomerase I and repair of genomic damage // Current Studies of Biotechnology / Zlatko, Kniewald i ost. (ur.).
Zagreb: Hrvatsko biotehnološko društvo, 2000. str. 15-18 (predavanje, domaća recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
DNA topoisomerase I and repair of genomic damage

Autori
Nagy, Biserka ; Furčić, Ivana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Current Studies of Biotechnology / Zlatko, Kniewald i ost. - Zagreb : Hrvatsko biotehnološko društvo, 2000, 15-18

Skup
Biotechnology and Biomedicine with international participation

Mjesto i datum
Zagreb, Hrvatska, 22-23.02.1999

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Xeroderma pigmentosum cells; topoisomerase I activity; DNA damage

Sažetak
Recent evidence indicates that unrepaired genomic damage influences the catalytic activities of DNA topoisomerases. DNA lesions such as base mismatches, pyrimidinic dimers, 6, 4-photoproducts, apurinic and apyrimidinic sites and others, enhance topoisomerase I mediated DNA cleavage. These findings suggest that topoisomerase activity can be influenced by spontaneous, as well as environmentally induced damages to DNA. In this study the catalytic activity of topoisomerase I was examined Xeroderma pigmentosum cell lines B and C and compared with the activity of normal human cells. The data show that topoisomerase I levels are higher in two repair-deficient cell lines. This provide novel insight into the mechanism of action of topoisomerases and raise new questions regarding mechanism of topoisomerase-targeting drugs.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
119118

Ustanove
Prirodoslovno-matematički fakultet, Zagreb