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Synthesis and anti-inflammatory activity of 1-thia-dibenzo[e, h]azulenes modified at position 8 (CROSBI ID 570663)

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Ozimec Landek, Ivana ; Pešić, Dijana ; Stanić, Barbara ; Hrvačić, Boška ; Merćep, Mladen ; Mesić, Milan Synthesis and anti-inflammatory activity of 1-thia-dibenzo[e, h]azulenes modified at position 8 // 1st European Workshop in Drug Synthesis Castelnuovo Berardenga, Italija, 14.05.2006-19.05.2006

Podaci o odgovornosti

Ozimec Landek, Ivana ; Pešić, Dijana ; Stanić, Barbara ; Hrvačić, Boška ; Merćep, Mladen ; Mesić, Milan

engleski

Synthesis and anti-inflammatory activity of 1-thia-dibenzo[e, h]azulenes modified at position 8

1-Thia-dibenzo[e, h]azulene derivatives were found to be new potent molecules with antiinflammatory activity. One of the main research goals was to investigate the way modifications of different sites at 1-thia-dibenzo[e, h]azulene scaffold affect biological activity. The most obvious and synthetically very interesting modification appeared to be exchange of different heteroatoms (O, S and N) and CH2 group at position 8. We have searched for the most efficient and economic route, which would use the common synthetic intermediate as early as possible. Antiinflammatory activity of target molecules was determined in vitro and in vivo as inhibition of the key proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha).

1-thia-8-oxa-dibenzo[e; h]azulenes; 1; 8-dithia-dibenzo[e; h]azulenes; 8H-1-thia-8-aza-dibenzo[e; h]azulenes; 8H-2-thia-dibenzo[e; h]azulenes

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Podaci o prilogu

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Podaci o skupu

1st European Workshop in Drug Synthesis

poster

14.05.2006-19.05.2006

Castelnuovo Berardenga, Italija

Povezanost rada

Kemija, Temeljne medicinske znanosti