Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives (CROSBI ID 570626)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Alešković, Marija ; Basarić, Nikola ; Mlinarić-Majerski, Kata Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives // XXII. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA. Zagreb, 2011. str. 222-x

Podaci o odgovornosti

Alešković, Marija ; Basarić, Nikola ; Mlinarić-Majerski, Kata

engleski

Optimization of the Suzuki coupling reaction in the synthesis of 2-[(2-substituted)phenyl]pyrrole derivatives

The strategy for the synthesis of pyrrole derivatives having molecular skeletons similar to 1 and 2 was mostly based on tedious multistep synthetic procedures involving a condensation of the pyrrole ring. On the other hand, modern synthetic methods more often rely on the versatile use of Pd catalyzed C-C bond formation. [1] Herein, we describe a facile three-step synthetic protocol for the preparation of pyrrole derivatives 1 and 2 that involves Suzuki coupling of the N-protected pyrrole boronic acid 3 and nitrophenyl or cyanophenyl derivative, and subsequent hydrogenation to the corresponding amine. The Pd catalyzed cross coupling reaction is optimized, keeping in mind the easy availability of the reagents used in the synthesis, particularly inexpensive commercial catalysts and ligands. The scope of the reaction was tested on a wide range of substitued aryl halogenides, both with electron-donating and electron-withdrawing substituents, 4a-g. [2]

Suzuki coupling; pyrroles; aryles

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

222-x.

2011.

objavljeno

Podaci o matičnoj publikaciji

XXII. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA

Zagreb:

Podaci o skupu

XXII.Hrvatski skup kemičara i kemijskih inženjera

poster

13.02.2011-16.02.2011

Zagreb, Hrvatska

Povezanost rada

Kemija