Synthesis of novel sorafenib derivatives with pronounced cytostatic activity (CROSBI ID 570524)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Babić, Željka ; Crkvenčić, Maja ; Rajić, Zrinka ; Mikecin, Ana-Matea ; Kralj, Marijeta ; Balzarini, Jan ; Zorc, Branka
engleski
Synthesis of novel sorafenib derivatives with pronounced cytostatic activity
Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a-e which differ from sorafenib in their amide part. All compounds are fully chemically characterized and evaluated for their cytostatic activity in vitro. In addition, their antiviral and antituberculotic potentials were investigated as well.
sorafenib; amide; cytostatic activity; synthesis
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Podaci o prilogu
220-220.
2011.
objavljeno
Podaci o matičnoj publikaciji
XXII. hrvatski skup kemičara i kemijskih inženjera : knjiga sažetaka = book of abstracts]
Tomašić, Vesna ; Maduna Valkaj, Karolina
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
9789536894420
Podaci o skupu
Hrvatski skup kemičara i kemijskih inženjera (22 ; 2011)
poster
13.02.2011-16.02.2011
Zagreb, Hrvatska
