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Pregled bibliografske jedinice broj: 499863

CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S DISEASE


Hojsak, Iva; Petković, Iskra; Mišak, Zrinjka; Kolaček, Sanja.
CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S DISEASE // Journal of Pediatric Gastroenterology and Nutrition
Istanbul, Turska, 2010. str. 66-67 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 499863 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S DISEASE
(CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S)

Autori
Hojsak, Iva ; Petković, Iskra ; Mišak, Zrinjka ; Kolaček, Sanja.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Pediatric Gastroenterology and Nutrition / - , 2010, 66-67

Skup
ESPGHAN Annual Meeting

Mjesto i datum
Istanbul, Turska, 9.-12.6.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
celiac disease; Crohn's disease; chromosomal aberrations

Sažetak
Objectives and Study: We have recently shown that paediatric patients with newly diagnosed celiac disease (CED) have an increased number of chromosomal aberrations in peripheral blood lymphocytes and that gluten-free diet has a significant lowering effect on their number (1, 2). Chronic inflammation and the chromosomal instability have been both linked to an increased risk of malignancy (3), and chronic gastrointestinal diseases such as CED and Crohn’s disease (CD) have also been associated with the elevated malignancy risk (4, 5). We have, therefore, decided to determine the number of chromosomal aberrations in peripheral blood lymphocytes in patients with newly diagnosed, untreated CD and CED. Methods: In the 2.5 years period (06/2006 to 12/2008) we included 44 patients in the study ; 19 patients with newly diagnosed CED (12/19 female, age range 1–16 y, mean 6.9 y) ; 13 patients with newly diagnosed CD before any treatment was started (9/13 female, age range 7–17 y, mean 12 y), and 12 healthy controls (8/12 female, age range 1–18 y, mean 8.5 y). CD and CED group did not differ compared to controls in regard to age and gender (P = 0.5, P = 0.07, P = 0.8, P = 0.9, respectively). Chromosome aberrations were analyzed in peripheral blood lymphocytes. For each subject 100 metaphases were analyzed for chromosome-type (breaks, gaps, exchange, acentric and dicentric fragments and ring chromosome) and chromatid-type aberrations (breaks, gaps, and chromatid exchange). A single cytogeneticist, who was blinded to the origin of the cells and was not involved in the treatment of the patients, performed the analyses. Results: In comparison to healthy controls (mean 4 aberrations/ 100 metaphases), a significantly increased overall number of aberrations was found in, both, CED (mean 6.8 aberrations/100 metaphases) and in CD group (mean 6.2 aberrations/100 metaphases) (P = 0.003, P = 0.04, respectively). Increased number of aberrant cells was also found in CED (mean 6.4) and CD (mean 5.5) group compared to controls (mean 4) (P = 0.002, P = 0.04, respectively). There was no statistically significant difference between CD and CED groups in regard to overall number of aberrations and aberrant cells (P = 0.47, P = 0.27, respectively). Conclusion: Patients with active CED and newly diagnosed CD, before treatment was initiated, have significantly increased number of chromosomal aberrations in peripheral blood lymphocytes. This could be the link between the chronic inflammation and the increased risk for malignancy in both disorders.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
072-1083107-0361 - Telomere i kromosomske aberacije u patologiji dječje dobi (Petković, Iskra, MZOS - )
072-1083107-2054 - Celijakija u djece: primarna prevencija i patogeneza kromosomske nestabilnosti (Kolaček, Sanja, MZOS - )

Ustanove
Klinika za dječje bolesti Medicinskog fakulteta

Profili:

Avatar Url Iskra Petković (autor)

Avatar Url Zrinjka Mišak (autor)

Avatar Url Sanja Kolaček (autor)

Avatar Url Iva Hojsak (autor)

Citiraj ovu publikaciju

Hojsak, Iva; Petković, Iskra; Mišak, Zrinjka; Kolaček, Sanja.
CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S DISEASE // Journal of Pediatric Gastroenterology and Nutrition
Istanbul, Turska, 2010. str. 66-67 (poster, međunarodna recenzija, sažetak, znanstveni)
Hojsak, I., Petković, I., Mišak, Z. & Kolaček, S. (2010) CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S DISEASE. U: Journal of Pediatric Gastroenterology and Nutrition.
@article{article, year = {2010}, pages = {66-67}, keywords = {celiac disease, Crohn's disease, chromosomal aberrations}, title = {CHROMOSOMAL ABERRATIONS IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH NEWLY DIAGNOSED CELIAC AND CROHN’S}, keyword = {celiac disease, Crohn's disease, chromosomal aberrations}, publisherplace = {Istanbul, Turska} }




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