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Pregled bibliografske jedinice broj: 498038

Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) in breast cancer patients


Beketić-Orešković, Lidija; Ozretić, Petar; Rabbani, Zahid N.; Jackson, Isabel L.; Šarčević, Božena; Levanat, Sonja; Marić, Petra; Babić, Ivan; Vujasković, Željko
Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) in breast cancer patients // Pathology and Oncology Research, 17 (2011), 3; 593-603 doi:10.1007/s12253-010-9355-6 (međunarodna recenzija, članak, znanstveni)


Naslov
Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) in breast cancer patients

Autori
Beketić-Orešković, Lidija ; Ozretić, Petar ; Rabbani, Zahid N. ; Jackson, Isabel L. ; Šarčević, Božena ; Levanat, Sonja ; Marić, Petra ; Babić, Ivan ; Vujasković, Željko

Izvornik
Pathology and Oncology Research (1219-4956) 17 (2011), 3; 593-603

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
8-OHdG; breast cancer; CA-IX; CD105; survival analysis

Sažetak
The aim of this study was to examine the prognostic significance of carbonic anhydrase IX (CA-IX), an endogenous marker for tumor hypoxia ; endoglin (CD105), a proliferation-associated and hypoxia-inducible glycoprotein and 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA lesion, in breast cancer patients. Immunohistochemical expressions of CA-IX, CD105 and 8-OHdG, analyzed on paraffin-embedded tumor tissues from forty female breast cancer patients, were used to assess their prognostic implication on overall survival (OS) and relapse-free survival (RFS). Patients with high CA-IX expression (above cut-off value) had a higher occurrence of relapse (P=0.002). High CA-IX expression was significantly associated with shorter RFS (P<0.001, hazard ratio (HR) 0.21) and shorter OS (P<0.001, HR 0.19). Lymph node negative patients with high CA-IX expression had worse RFS (P=0.031, HR 0.14) and OS (P=0.005, HR 0.05). Patients with grade I&II tumors and high CA-IX expression showed shorter RFS (P=0.028, HR 0.28) and OS (P=0.008, HR 0.20). Worse OS (P=0.046, HR 0.28) was found in subgroup of patients with grade II tumors and high CA-IX expression. Among all three markers, only high CA-IX expression was strong independent prognostic indicator for shorter OS (HR 4.14, 95% CI 1.28-13.35, P=0.018) and shorter RFS (HR 3.99, 95% CI 1.38-11.59, P=0.011). Elevated expression of CA-IX was an independent prognostic factor for decreased RFS and OS and a significant marker for tumor aggressiveness. CD105 had week prognostic value ; whereas, 8-OHdG, in this study, did not provide sufficient evidence as a prognostic indicator in breast cancer patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
074-0982464-1187 - KLINIČKO ZNAČENJE TUMORSKE HIPOKSIJE U BOLESNIKA LIJEČENIH RADIOTERAPIJOM (Lidija Beketić-Orešković, )
098-0982464-2461 - Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije (Sonja Levanat, )

Ustanove
Klinika za tumore,
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Abstracts in Anthropology
  • BIOSIS Previews (Biological Abstracts)
  • CAB Abstracts
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE


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