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Pregled bibliografske jedinice broj: 498036

Tumor Markers in Breast Cancer – Evaluation of their Clinical Usefulness


Marić, Petra; Ozretić, Petar; Levanat, Sonja; Orešković, Slavko; Antunac , Katarina; Beketić-Orešković, Lidija
Tumor Markers in Breast Cancer – Evaluation of their Clinical Usefulness // Collegium Antropologicum, 35 (2011), 1; 241-247 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Tumor Markers in Breast Cancer – Evaluation of their Clinical Usefulness

Autori
Marić, Petra ; Ozretić, Petar ; Levanat, Sonja ; Orešković, Slavko ; Antunac , Katarina ; Beketić-Orešković, Lidija

Izvornik
Collegium Antropologicum (0350-6134) 35 (2011), 1; 241-247

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Breast cancer; serum tumor markers; tissue tumor markers; genetic tumor markers; clinical application

Sažetak
Breast cancer is the most common neoplasm affecting women in the Western world. Many studies are still conducted with the purpose of finding markers that could be used for early diagnosis and/or serve as possible reliable prognostic or predictive parameters, but with conflicting results. At present, no markers are available for an early diagnosis of breast cancer. For surveillance of patients with diagnosed breast cancer the most widely used serum markers are CA 15-3 and CEA which, in combination with other clinical parameters, could have clinical significance. The most useful and clinically important tissue-based markers in breast cancer are estrogen and progesterone receptors, used as a basis for hormonal therapy, and HER-2 receptors, essential in selecting patients for the treatment with Herceptin®. New or potentially new markers for breast cancer include BRCA1 and BRCA2 genes for selecting patients at high risk of developing hereditary breast cancer, as well as urokinase plasminogen activator and inhibitor for assessing prognosis in lymph node-negative patients. Results of tumor and patient genetic analyses including their clinical evaluation will enable application of more individualized and personalized approach in diagnosis and therapy of breast cancer patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
074-0982464-1187 - KLINIČKO ZNAČENJE TUMORSKE HIPOKSIJE U BOLESNIKA LIJEČENIH RADIOTERAPIJOM (Lidija Beketić-Orešković, )

Ustanove
Klinika za tumore,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Abstracts in Anthropology
  • Anthropological Literature
  • International Bibliography of the Social Sciences (IBSS)
  • MEDLINE
  • Sociological Abstracts