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Pregled bibliografske jedinice broj: 497994

EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma


Đorđević, Gordana; Matušan-Ilijaš, Koviljka; Hadžisejdić, Ita; Maričić, Anton; Grahovac, Blaženka; Jonjić, Nives
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma // Journal of biomedical science, 19 (2012), 40-1 doi:10.1186/1423-0127-19-40 (međunarodna recenzija, članak, znanstveni)


Naslov
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma

Autori
Đorđević, Gordana ; Matušan-Ilijaš, Koviljka ; Hadžisejdić, Ita ; Maričić, Anton ; Grahovac, Blaženka ; Jonjić, Nives

Izvornik
Journal of biomedical science (1021-7770) 19 (2012); 40-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
carcinoma; renal cell; chromosome 7; EGFR; In Situ hybridization; fluorescence; prognosis

Sažetak
The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic significance of EGFR expression in clear cell renal cell carcinoma (CCRCC). The present study was designed to analyze more objectively the protein EGFR expression in CCRCC and to compare its value with EGFR gene copy number changes and clinicopathologic characteristics including patient survival. The protein EGFR expression was analyzed immunohistochemically on 94 CCRCC, and gene copy number alterations of EGFR by FISH analysis on 41 CCRCC selected according to distinct membrane EGFR staining. Membrane EGFR expression in tumor cells was heterogeneous with respect to the proportion of positive cells and staining intensity. FISH analysis did not reveal EGFR gene amplification, while polysomy of chromosome 7 found in 41% was associated with higher EGFR membrane expression. Moreover, EGFR overexpression was associated with a higher nuclear grade, larger tumor size and shorter patient’s survival, while there was no connection with pathological stage. In conclusion, the protein expression of EGFR had an impact on prognosis in patients with CCRCC, while an increased copy number of chromosome 7 could be the possible reason for EGFR protein overexpression in the absence of gene amplification.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Nives Jonjić, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

Đorđević, Gordana; Matušan-Ilijaš, Koviljka; Hadžisejdić, Ita; Maričić, Anton; Grahovac, Blaženka; Jonjić, Nives
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma // Journal of biomedical science, 19 (2012), 40-1 doi:10.1186/1423-0127-19-40 (međunarodna recenzija, članak, znanstveni)
Đorđević, G., Matušan-Ilijaš, K., Hadžisejdić, I., Maričić, A., Grahovac, B. & Jonjić, N. (2012) EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. Journal of biomedical science, 19, 40-1 doi:10.1186/1423-0127-19-40.
@article{article, year = {2012}, pages = {40-1-40-8}, DOI = {10.1186/1423-0127-19-40}, keywords = {carcinoma, renal cell, chromosome 7, EGFR, In Situ hybridization, fluorescence, prognosis}, journal = {Journal of biomedical science}, doi = {10.1186/1423-0127-19-40}, volume = {19}, issn = {1021-7770}, title = {EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma}, keyword = {carcinoma, renal cell, chromosome 7, EGFR, In Situ hybridization, fluorescence, prognosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE


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