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Pregled bibliografske jedinice broj: 49709

Glucose tolerance in acromegaly


Aganović, Izet; Koršić, Mirko; Giljević, Zlatko; Perković, Zdravko; Škorić, Tanja
Glucose tolerance in acromegaly // Scientific Program / Sereday, Martha (ur.).
Buenos Aires, Argentina, 1999. str. 4-4 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 49709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glucose tolerance in acromegaly

Autori
Aganović, Izet ; Koršić, Mirko ; Giljević, Zlatko ; Perković, Zdravko ; Škorić, Tanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Scientific Program / Sereday, Martha - Buenos Aires, Argentina, 1999, 4-4

Skup
Primera Reunion Cientifica Conjunta - GLED/EDEG

Mjesto i datum
Buenos Aires, Argentina, 5-8.04.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acromegaly; diabetes mellitus; impaired glucose tolerance

Sažetak
Acromegaly is a rare disorder characterized by hypersecretion of growth hormone (GH), and in more than 99 percent of cases is due to a functioning pituitary adenoma. It is associated with an increased incidence of cardiovascular disease and several disturbances in intermediary metabolism, including insulin resistance, hyperinsulinaemia and increased metabolic rate. 20 percent of acromegalic patients are diabetic and 40 percent have impaired glucose tolerance (IGT). Overall mortality in acromegaly is approximately double that found in general population. Of ninety-eight (98) pituitary adenoma patients admitted to our Department during the period from 1991-1997, fifteen (15/98, 15.3 percent) had GH-secreting pituitary adenoma. The mean age of the patients was 49.9+-10.4. There were eight women (BMI 32.0+-4.2 kg/m2) and seven men (BMI 28.5+-3.6 kg/m2). Six patients had micro- and nine patients had macro-adenoma as revealed by CT or MRI. Mean basal plasma GH concentration was 29.7+-24.6 mIU/L (normal range less than 0.3-14 mIU/L). A 100-g oral glucose tolerance test (OGTT) failed to supress the plasma GH to less than 4.0 mIU/L in all patients. Eight of 15 patients had increased fasting blood glucose levels. Two female patients had a history of diabetes mellitus (DM) for 3 and 11 years before acromegaly was diagnosed and they had both taken oral antidiabetics. The OGTT identified 4 out of 15 patients with IGT (26.6 percent) and the same number of patients with DM. Our results show the significant number of acromegalic patients with IGT or DM.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108116

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zlatko Giljević (autor)

Avatar Url Mirko Koršić (autor)

Avatar Url Tanja Škorić (autor)

Avatar Url Izet Aganović (autor)


Citiraj ovu publikaciju:

Aganović, Izet; Koršić, Mirko; Giljević, Zlatko; Perković, Zdravko; Škorić, Tanja
Glucose tolerance in acromegaly // Scientific Program / Sereday, Martha (ur.).
Buenos Aires, Argentina, 1999. str. 4-4 (poster, međunarodna recenzija, sažetak, znanstveni)
Aganović, I., Koršić, M., Giljević, Z., Perković, Z. & Škorić, T. (1999) Glucose tolerance in acromegaly. U: Sereday, M. (ur.)Scientific Program.
@article{article, author = {Aganovi\'{c}, Izet and Kor\v{s}i\'{c}, Mirko and Giljevi\'{c}, Zlatko and Perkovi\'{c}, Zdravko and \v{S}kori\'{c}, Tanja}, editor = {Sereday, M.}, year = {1999}, pages = {4-4}, keywords = {acromegaly, diabetes mellitus, impaired glucose tolerance}, title = {Glucose tolerance in acromegaly}, keyword = {acromegaly, diabetes mellitus, impaired glucose tolerance}, publisherplace = {Buenos Aires, Argentina} }
@article{article, author = {Aganovi\'{c}, Izet and Kor\v{s}i\'{c}, Mirko and Giljevi\'{c}, Zlatko and Perkovi\'{c}, Zdravko and \v{S}kori\'{c}, Tanja}, editor = {Sereday, M.}, year = {1999}, pages = {4-4}, keywords = {acromegaly, diabetes mellitus, impaired glucose tolerance}, title = {Glucose tolerance in acromegaly}, keyword = {acromegaly, diabetes mellitus, impaired glucose tolerance}, publisherplace = {Buenos Aires, Argentina} }




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