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Pregled bibliografske jedinice broj: 49700

Cushing's disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study)


Kaštelan, Darko; Koršić, Mirko; Giljević, Zlatko; Breskovac, Ljiljana; Breskovac, Ljiljana; Perković, Zdravko; Jelčić, Jozo; Aganović, Izet; Škorić, Tanja; Plavšić, Vesna
Cushing's disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study) // Abstracts PA-43
Odense, Danska, 1999. str. 93-93 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 49700 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cushing's disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study)

Autori
Kaštelan, Darko ; Koršić, Mirko ; Giljević, Zlatko ; Breskovac, Ljiljana ; Breskovac, Ljiljana ; Perković, Zdravko ; Jelčić, Jozo ; Aganović, Izet ; Škorić, Tanja ; Plavšić, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts PA-43 / - Odense, Danska, 1999, 93-93

Skup
9th Meeting of the European Neuroendocrine Association

Mjesto i datum
Odense, Danska, 3-7.09.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cushing's disease; pituitary insufficiency

Sažetak
Cushing's disease is a hypercortisolemic state due to an adrenocorticotropic hormone producing pituitary adenoma. Transsphenoidal surgery is a treatment of choice for Cushing's disease. A retrospective study of 12 patients (8 women, 4 men) with Cushing's disease undergoing transsphenoidal surgery at the University Hospital Centre Zagreb, from 1991 to 1998, is presented. There were 10 microadenomas and 2 macroadenomas. Selective surgery was done if tumor was seen, and more extensive surgery if has not, or if tumor was diffuse. Patients were followed for a median time of 31 months (range: 6-84). Remission rate was 50 percent.Criteria for failures were loss of the normal circadian rhythm of serum cortisol and urinary free cortisol above 250 nmol/day, within the first year after operation. Of all six failures, two underwent succesful operation, other two underwent bilateral adrenalectomy and one is still awaiting surgery. Two patients (16 percent) had cerebrovascular fluid leak, but none developed meningitis. All but one patient developed postoperative pituitary insufficiency which is diagnosed on the basis of low hormone answers in stimulation tests (TRH, LH-RH and insulin test). Two patients (16 percent) developed permanent diabetes insipidus, 11/12 patients (91 percent) had ACTH deficiency, 9/12 patients (75 percent) developed hypogonadism and 8/12 patients (66 percent) became hypothyroid. Our results, with a cumulative remission rate of 66 percent, are comparable to those of other studies, but the rate of postoperative pituitary insufficiency was unexpectedly high.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108116

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju:

Kaštelan, Darko; Koršić, Mirko; Giljević, Zlatko; Breskovac, Ljiljana; Breskovac, Ljiljana; Perković, Zdravko; Jelčić, Jozo; Aganović, Izet; Škorić, Tanja; Plavšić, Vesna
Cushing's disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study) // Abstracts PA-43
Odense, Danska, 1999. str. 93-93 (poster, međunarodna recenzija, sažetak, znanstveni)
Kaštelan, D., Koršić, M., Giljević, Z., Breskovac, L., Breskovac, L., Perković, Z., Jelčić, J., Aganović, I., Škorić, T. & Plavšić, V. (1999) Cushing's disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study). U: Abstracts PA-43.
@article{article, author = {Ka\v{s}telan, Darko and Kor\v{s}i\'{c}, Mirko and Giljevi\'{c}, Zlatko and Breskovac, Ljiljana and Breskovac, Ljiljana and Perkovi\'{c}, Zdravko and Jel\v{c}i\'{c}, Jozo and Aganovi\'{c}, Izet and \v{S}kori\'{c}, Tanja and Plav\v{s}i\'{c}, Vesna}, year = {1999}, pages = {93-93}, keywords = {Cushing and \#39, s disease, pituitary insufficiency}, title = {Cushing and \#39;s disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study)}, keyword = {Cushing and \#39, s disease, pituitary insufficiency}, publisherplace = {Odense, Danska} }
@article{article, author = {Ka\v{s}telan, Darko and Kor\v{s}i\'{c}, Mirko and Giljevi\'{c}, Zlatko and Breskovac, Ljiljana and Breskovac, Ljiljana and Perkovi\'{c}, Zdravko and Jel\v{c}i\'{c}, Jozo and Aganovi\'{c}, Izet and \v{S}kori\'{c}, Tanja and Plav\v{s}i\'{c}, Vesna}, year = {1999}, pages = {93-93}, keywords = {Cushing and \#39, s disease, pituitary insufficiency}, title = {Cushing and \#39;s disease at University Hospital Center Zagreb - Results of transsphenoidal surgery treatment (Retrospective study)}, keyword = {Cushing and \#39, s disease, pituitary insufficiency}, publisherplace = {Odense, Danska} }




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