engleski

Local Drug Delivery for Oral Mucosal Diseases : Challenges and Opportunities

There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilising these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue penetration and accidental swallowing. In this review we discuss common mucosal diseases such as oral cancer, mucositis, vesiculo-erosive conditions, infections, neuropathic pain and salivary dysfunction which could benefit from topical delivery systems designed specifically for the oral mucosa which are capable of sustained release. Each condition requires distinct penetration and drug retention profiles in order to optimise treatment and minimise side effects. Local drug delivery may provide a more targeted and efficient drug delivery option than systemic delivery for diseases of the oral mucosa. We identify those mucosal diseases currently being treated, the challenges that must be overcome and the potential of novel therapies. Novel biological therapies such as macromolecular biological drugs, peptides, and gene therapy may be of value in the treatment of many chronic oral conditions and thus in oral medicine if their delivery can be optimised.

drug delivery; oral mucosa; mucosal disease; trans-mucosal

Rad je prezentiran na skupu The Fifth World Workshop on Oral Medicine : Systematic Reviews and Position Papers on Future Directions for International Specialty Training, Practice and Research.