Role of 5-HT1A receptors in induction and preservation of phrenic long-term facilitation in rats (CROSBI ID 168148)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pavlinac, Ivana ; Pecotić, Renata ; Đogaš, Zoran ; Valić, Maja
engleski
Role of 5-HT1A receptors in induction and preservation of phrenic long-term facilitation in rats
The aim was to investigate the role of 5-HT(1A) receptor activation in induction and preservation of phrenic long-term facilitation (pLTF) at two different time points, before exposures to episodic hypoxia and after pLTF was induced. Adult, male, urethane anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed to an acute intermittent hypoxia (AIH) protocol. Experimental groups of animals received an intravenous injection of WAY-100635, before the onset of the first hypoxic stimulus (WAY0), and after pLTF was induced (WAY60). Peak phrenic nerve activity (pPNA), burst frequency (f), and respiratory rhythm parameters were analyzed during the five hypoxic exposures (TH1-5), as well as at 15min (T15), 30min (T30), and 60min (T60) after the end of the last hypoxic episode. In the control group, pPNA was elevated from baseline (121.6±7.3%, P<0.001) at 60min after episodic hypoxia indicating pLTF. Administration of WAY-100635 prior to hypoxic stimulation prevented the induction of pLTF. Additionally, administration of WAY-100635 after pLTF developed impaired preservation of pLTF. In conclusion, there is an important role for 5-HT(1A) receptors in induction as well as in preservation of pLTF in urethane anesthetized rats
phrenic nerve; intermittent hypoxia; serotonin
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Podaci o izdanju
175 (1)
2011.
146-152
objavljeno
1569-9048
10.1016/j.resp.2010.10.005
Povezanost rada
Temeljne medicinske znanosti