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Pregled bibliografske jedinice broj: 495654

Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains


Plyusnina, Angelina; Cvetko Krajinović, Lidija; Margaletić, Josip; Niemimaa, Jukka; Nemirov, Kirill; Lundkvist, Åke; Markotić, Alemka; Miletić-Medved, Marica; Avšič-Županc, Tatjana; Henttonen, Heikki; Plyusnin, Alexander
Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains // Journal of medical virology, 83 (2011), 1; 108-114 doi:10.1002/jmv.21929 (međunarodna recenzija, članak, znanstveni)


Naslov
Genetic evidence for the presence of two distinct hantaviruses associated with Apodemus mice in Croatia and analysis of local strains

Autori
Plyusnina, Angelina ; Cvetko Krajinović, Lidija ; Margaletić, Josip ; Niemimaa, Jukka ; Nemirov, Kirill ; Lundkvist, Åke ; Markotić, Alemka ; Miletić-Medved, Marica ; Avšič-Županc, Tatjana ; Henttonen, Heikki ; Plyusnin, Alexander

Izvornik
Journal of medical virology (0146-6615) 83 (2011), 1; 108-114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hantaviruses; HFRS; zoonoses; Croatia; epidemiology

Sažetak
In Europe, Dobrava-Belgrade (DOBV), Saaremaa (SAAV), and Puumala (PUUV) viruses are known to cause hemorrhagic fever with renal syndrome (HFRS). All three hantaviruses are now found in Croatia. Lung tissue samples of 315 Apodemus mice trapped in 2003-2004 were screened for the presence of hantaviral N-Ag and 20 mice (6.3%) were found either strongly positive or weak/suspected-positive. Partial sequences of hantavirus M and S segments were recovered by RT-PCR from six mice and subjected to (phylo)genetic analysis that revealed the presence of four novel strains of DOBV and one of SAAV. Curiously, one of the newly described DOBV strains was found in Apodemus agrarius mouse, that is, not in the traditional host, A. flavicollis mice, suggesting a spillover event. S segment sequences recovered previously from HFRS cases [Markotić et al., 2002] were confirmed as DOBV sequences ; one of which appeared particularly close to the prototype Slovenian DOBV isolate. Taken together with earlier data on PUUV in Croatia, these results show a co-circulation of three European hantavirus pathogens in this country. So far, not a single SAAV sequence has been recovered from HFRS patients either in Croatia or neighboring Slovenia and Hungary nor in Slovakia suggesting a somewhat lower fequency of acute SAAV infection in humans in this part of Europe than for example in the Baltics.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
068-1430115-2119 - Šumski ekosustavi kao prirodna žarišta hantavirusa i leptospira (Josip Margaletić, )
143-1430115-0103 - Imunoreakcije na hantaviruse i leptospire (Alemka Markotić, )

Ustanove
Šumarski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati