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Intraluminal brachytherapy in the management of squamous carcinoma of the esophagus


Frobe, Ana; Jones, Glenn; Jakšić, Blanka; Bokulić, Tomislav; Budanec, Mirjana; Mrčela, Iva; Staničić-Rokotov, Dinko; Hrabar, Davor; Bolanča, Ante; Rosenblatt, Eduardo; Kusić, Zvonko
Intraluminal brachytherapy in the management of squamous carcinoma of the esophagus // Diseases of the esophagus, 22 (2009), 6; 513-518 doi:10.1111/j.1442-2050.2009.00958.x (međunarodna recenzija, članak, znanstveni)


Naslov
Intraluminal brachytherapy in the management of squamous carcinoma of the esophagus

Autori
Frobe, Ana ; Jones, Glenn ; Jakšić, Blanka ; Bokulić, Tomislav ; Budanec, Mirjana ; Mrčela, Iva ; Staničić-Rokotov, Dinko ; Hrabar, Davor ; Bolanča, Ante ; Rosenblatt, Eduardo ; Kusić, Zvonko

Izvornik
Diseases of the esophagus (1120-8694) 22 (2009), 6; 513-518

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brachytherapy high dose rate; dysphagia; esophageal cancer; palliative care; quality of life

Sažetak
Intraluminal high dose rate brachytherapy (ILHDR BT) is one of several effective modalities for palliation of advanced esophageal cancer. Thirty patients with endoscopic-proven, mostly locally advanced, squamous cell carcinoma of the esophagus, not involving the gastroesophageal junction and without distant metastases, were included in this analysis. Twenty-nine patients received two ILHDR BT sessions of 8 Gy within a week and one patient received only one session. All patients were followed monthly. Outcomes included quality of life (QOL), symptoms control: dysphagia, regurgitation, odynophagia, and chest or back pain, as well as, overall survival. Through 4 months of follow-up, QOL was statistically improved (having lowered scores) in regards to feelings (P= 0.013), sleeping (P= 0.032), eating (P= 0.020), and social life (P= 0.002). The most significantly improved symptom was dysphagia (P < 0.006), with a reduction of 0.52 units or one-half grade. Regurgitation, odynophagia, and pain were lower during follow-up but were not statistically significant. The median overall survival from death of any cause was 165 days (with a 95% confidence interval of 128–195 days). In conclusion, ILHDR BT of advanced squamous esophageal cancer consisting of two out-patient procedures is very successful in achieving the primary objectives of the patients to reduce dysphagia and improve QOL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
134-1342428-2430 - Karcinogeneza u štitnjači i gušavost u Hrvatskoj (Zvonko Kusić, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Academic Search Complete


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