engleski

Phenyl-imidazolium and quinuclidinium oximes as antidotes against organophosphorous and carbamate poisoning

The in vitro activity of human erythrocyte acetylcholinesterase (AChE) and protective activity against soman, dichlorvos, and propoxur poisoning in male mice (in vivo experiments) were determined by using bis- phenyl imidazolium (2B) and imidazole- quinuclidinium oximes (BM-1). Oxime 2B strongly inhibits the AChE, and has a good reactivation potency, but weak protective ability, against AChe inhibited by these agents. Oxime BM-1 inhibits weakly AChE and its in vitro activity against inhibited AChE is negligible. In vivo, this oxime is a very good protective agent agains inhibitors tested in this paper. BM-1, given with atropine sulphate, provided a 100% protection in male mice against 4 x LD 50 soman, 11 x LD 50 dichlorovos, and 16 x LD 50 propoxur, respectively. The results indicate that in vivo effectiveness of quinuclidinium oxime is not related to its reactivating or protective potentials for AChE, as shown by the in vitro experiments. The in vivo action of this BM-1 oxime must be attributed to mechanisms not yet well defined.

organophosphorus compounds ; carbamates ; AChE

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