Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node (CROSBI ID 569164)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Mustać, Elvira ; Matušan-Ilijaš, Koviljka ; Marijić, Blažen ; Smokvina, Aleksandar ; Jonjić, Nives
engleski
Histologic detection of additional nodal metastases in breast carcinoma with positive sentinel node
Axillary lymph node dissection (ALND) is an important procedure in the staging of breast cancer patients. A lymph node defined as sentinel lymph node (SLN) would be the first to receive tumoral drainage. The aim of this study was to estimate the likelihood of additional disease in the axilla after SLN mapping. A total of 259 breast carcinomas and SLN biopsies followed by ALND were examined. The patient median age was 59 years, approximately 75% of them postmenopausal. Tumor size was 1.4±0.8 cm (almost 80% in pT1). SLNs were positive in 59 of 259 (22.8%) carcinomas, 30 (11.6%) with micrometastases (<2.0 mm) and 29 (11.2%) with metastases. Tumor size (p=0.004) and presence of lymphovascular invasion (LVI) (p=0.034) were found to be significant predictors of pathologically positive SLN. Positive non-SLNs were present mostly in patients with metastasis >2 mm in SLN (p=0.003), in carcinoma with higher nuclear grade (p=0.044), decreased ER (p=0.042), and PR (p=0.042). Finally, lymph node status (pN) following SLN and ALND was found to be significantly associated with tumor size (p=0.006), LVI (p=0.037), PR (p=0.023) and Her-2 status (p<0.001). These results point to detailed analysis of primary tumor and SLN that may increase the precision of patient selection for further axillary surgery or radiotherapy.
additional lymph node metastases; breast carcinoma; Sentinel lymph node
DOI 10.1007/s00428-009-0805-z
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
180-180.
2009.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Virchows archiv
0945-6317
Podaci o skupu
European Congress of Pathology (22 ; 2009)
poster
04.09.2009-09.09.2009
Firenca, Italija
Povezanost rada
Kliničke medicinske znanosti