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Pregled bibliografske jedinice broj: 493811

A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties


Slavuljica, Irena; Busche, Andreas; Babić, Marina; Mitrović, Maja; Gašparović, Iva; Cekinović, Đurđica; Markova Car, Elitza; Pernjak Pugel, Ester; Ciković, Ana; Juranić Lisnić, Vanda et al.
A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties // Annual meeting of the Austrian Society for Allergology and Immunology-Book of abstracts
Beč, 2010. str. 21-21 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties

Autori
Slavuljica, Irena ; Busche, Andreas ; Babić, Marina ; Mitrović, Maja ; Gašparović, Iva ; Cekinović, Đurđica ; Markova Car, Elitza ; Pernjak Pugel, Ester ; Ciković, Ana ; Juranić Lisnić, Vanda ; Britt, William J. ; Koszinowski, Ulrich ; Messerle, Martin ; Krmpotić, Astrid ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Annual meeting of the Austrian Society for Allergology and Immunology-Book of abstracts / - Beč, 2010, 21-21

Skup
Annual meeting of the Austrian Society for Allergology and Immunology

Mjesto i datum
Beč, Austrija, 03-05.12.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; NKG2D; CMV vaccine

Sažetak
The authors propose a model where an engineered cytomegalovirus serves as a potential vaccine. Namely, a ligand for the strong activating NK cell receptors is inserted into a CMV-BAC, and this feature makes the virus strongly attenuated in vivo in both immunocompetent and immunodeficient hosts. Infection of mice with this virus however elicited strong, long-lasting protective immunity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Ester Pernjak-Pugel, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Slavuljica, Irena; Busche, Andreas; Babić, Marina; Mitrović, Maja; Gašparović, Iva; Cekinović, Đurđica; Markova Car, Elitza; Pernjak Pugel, Ester; Ciković, Ana; Juranić Lisnić, Vanda et al.
A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties // Annual meeting of the Austrian Society for Allergology and Immunology-Book of abstracts
Beč, 2010. str. 21-21 (poster, međunarodna recenzija, sažetak, znanstveni)
Slavuljica, I., Busche, A., Babić, M., Mitrović, M., Gašparović, I., Cekinović, Đ., Markova Car, E., Pernjak Pugel, E., Ciković, A. & Juranić Lisnić, V. (2010) A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties. U: Annual meeting of the Austrian Society for Allergology and Immunology-Book of abstracts.
@article{article, year = {2010}, pages = {21-21}, keywords = {MCMV, NKG2D, CMV vaccine}, title = {A ligand for the NKG2D receptor expressed by mouse CMV attenuates the virus, changes virus distribution and improves vaccine properties}, keyword = {MCMV, NKG2D, CMV vaccine}, publisherplace = {Be\v{c}, Austrija} }