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Pregled bibliografske jedinice broj: 493684

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction


Sotoodehnia, Nona; ...; Polašek, Ozren; Rudan, Igor; ...; Arking, D.E.
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction // Nature genetics, 42 (2010), 12; 1068-1076 doi:10.1038/ng.716 (međunarodna recenzija, članak, znanstveni)


Naslov
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Autori
Sotoodehnia, Nona ; ... ; Polašek, Ozren ; Rudan, Igor ; ... ; Arking, D.E.

Izvornik
Nature genetics (1061-4036) 42 (2010), 12; 1068-1076

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genome-wide; QRS

Sažetak
The QRS interval, from the beginning of the Q wave to the end of the S wave on an electrocardiogram, reflects ventricular depolarization and conduction time and is a risk factor for mortality, sudden death and heart failure. We performed a genome-wide association meta-analysis in 40, 407 individuals of European descent from 14 studies, with further genotyping in 7, 170 additional Europeans, and we identified 22 loci associated with QRS duration (P < 5 × 10(-8)). These loci map in or near genes in pathways with established roles in ventricular conduction such as sodium channels, transcription factors and calcium-handling proteins, but also point to previously unidentified biologic processes, such as kinase inhibitors and genes related to tumorigenesis. We demonstrate that SCN10A, a candidate gene at the most significantly associated locus in this study, is expressed in the mouse ventricular conduction system, and treatment with a selective SCN10A blocker prolongs QRS duration. These findings extend our current knowledge of ventricular depolarization and conduction.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
The CHARGE Consortium (102 koautora)



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Profili:

Avatar Url Igor Rudan (autor)

Avatar Url Ozren Polašek (autor)

Citiraj ovu publikaciju

Sotoodehnia, Nona; ...; Polašek, Ozren; Rudan, Igor; ...; Arking, D.E.
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction // Nature genetics, 42 (2010), 12; 1068-1076 doi:10.1038/ng.716 (međunarodna recenzija, članak, znanstveni)
Sotoodehnia, N., ..., Polašek, O., Rudan, I., ... & Arking, D. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature genetics, 42 (12), 1068-1076 doi:10.1038/ng.716.
@article{article, year = {2010}, pages = {1068-1076}, DOI = {10.1038/ng.716}, keywords = {genome-wide, QRS}, journal = {Nature genetics}, doi = {10.1038/ng.716}, volume = {42}, number = {12}, issn = {1061-4036}, title = {Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction}, keyword = {genome-wide, QRS} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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