Determination of aqueous stability and degradation products of series of coumarin dimers (CROSBI ID 167554)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dragojević, Snježana ; Šunjić, Vitomir ; Bencetić-Mihaljević, Vlatka ; Ralić, Jovica ; Mesić, Milan ; Jivkov Elenkov, Ivaylo ; Filipović Sučić, Anita ; Čempuh klonkay, Andreja ; Lerman, Lidija ; Ilijaš, Marina ; Gabelica-Marković, Vesna ; Malnar, Ivica
engleski
Determination of aqueous stability and degradation products of series of coumarin dimers
The stability in aqueous solution of five classes of coumarin dimers (I–V, compounds 1–29) was studied by HPLC–MS/MS at various pH values. The relationship between chemical structure and stability is discussed. It was found that dimeric compounds with strong electron withdrawing groups (EWGs) on the alfa-carbon to the bridging C-atom are stable at all pH values, whereas other derivatives undergo retro-Michael addition at rates which are also affected by the substituents on the aromatic rings. In some casesformation of stable isomers or oxidation products was observed. In order to evaluate their developability and potential for progression to in vivo studies, representative compounds were tested in an in vitro microsomal stability assay.
aqueous stability; coumarin dimers; HPLC-DAD-MS analysis; decomposition rate; metabolic stablity
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
54 (1)
2011.
37-47
objavljeno
0731-7085
10.1016/j.jpba.2010.08.002