Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 492542

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site


Spasojević, Ivan; Kos, Ivan; Benov, Ludmil T.; Rajić, Zrinka; Fels, Diane; Dedeugd, Casey; Ye, Xiaodong; Vujasković, Željko; Reboucas, Julio S.; Leong, Kam W. et al.
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site // Free radical research, 45 (2011), 2; 188-200 doi:10.3109/10715762.2010.522575 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 492542 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site

Autori
Spasojević, Ivan ; Kos, Ivan ; Benov, Ludmil T. ; Rajić, Zrinka ; Fels, Diane ; Dedeugd, Casey ; Ye, Xiaodong ; Vujasković, Željko ; Reboucas, Julio S. ; Leong, Kam W. ; Dewhirst, Mark W. ; Batinić-Haberle, Ines

Izvornik
Free radical research (1071-5762) 45 (2011), 2; 188-200

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SOD mimics; peroxynitrite scavengers; Mn(III) N-alkylpyridyl porphyrins

Sažetak
In the cell Mn porphyrins(MnPs) likely couple with cellular reductans which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to 3 orders of magnitude depending upon length of alkylpyridyl chains and type of isomer. The effects result from the interplay of solvation, lipophilcity and stericity. Impact of ascorbate on accumulation of MnPs was measured in E. coli and in Balb/C mouse tumors and muscle ; for the latter measurements, the LC/ESI-MS/MS method was developed. Accumulation was significantly enhanced when MnPs were co-administered with ascorbate in both prokaryotic and eukaryotic systems. Further, MnTnHex-2-PyP5+ accumulates 5-fold more in tumor than in surrounding muscle. Such data increase our understanding of MnPs cellular and subcellular accumulation and remarkable in vivo effects. The work is in progress to understand how coupling of MnPs with ascorbate affects their mechanism of action, in particular with respect to cancer therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivan Kos (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Ines Batinić-Haberle (autor)

Citiraj ovu publikaciju

Spasojević, Ivan; Kos, Ivan; Benov, Ludmil T.; Rajić, Zrinka; Fels, Diane; Dedeugd, Casey; Ye, Xiaodong; Vujasković, Željko; Reboucas, Julio S.; Leong, Kam W. et al.
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site // Free radical research, 45 (2011), 2; 188-200 doi:10.3109/10715762.2010.522575 (međunarodna recenzija, članak, znanstveni)
Spasojević, I., Kos, I., Benov, L., Rajić, Z., Fels, D., Dedeugd, C., Ye, X., Vujasković, Ž., Reboucas, J. & Leong, K. (2011) Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. Free radical research, 45 (2), 188-200 doi:10.3109/10715762.2010.522575.
@article{article, year = {2011}, pages = {188-200}, DOI = {10.3109/10715762.2010.522575}, keywords = {SOD mimics, peroxynitrite scavengers, Mn(III) N-alkylpyridyl porphyrins}, journal = {Free radical research}, doi = {10.3109/10715762.2010.522575}, volume = {45}, number = {2}, issn = {1071-5762}, title = {Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site}, keyword = {SOD mimics, peroxynitrite scavengers, Mn(III) N-alkylpyridyl porphyrins} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font