Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 492533

Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo


Rajić, Zrinka; Benov, Ludmil; Kos, Ivan; Tovmasyan, Artak; Batinic-Haberle, Ines
Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo // Free Radical Biology & Medicine / Kelvin J. A. Davis (ur.).
Orlando, USA: Elsevier, 2010. str. S194-S194 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 492533 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo

Autori
Rajić, Zrinka ; Benov, Ludmil ; Kos, Ivan ; Tovmasyan, Artak ; Batinic-Haberle, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Free Radical Biology & Medicine / Kelvin J. A. Davis - : Elsevier, 2010, S194-S194

Skup
SFRBM's 17th Annual Meeting

Mjesto i datum
Orlando, USA, 17.11.-21.11.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Mn porphyrins; ascorbic acid; SOD mimics; antioxidant; pro-oxidant

Sažetak
Historically cationic Mn(III) N-alkylpyridylporphyrins(MnTalkyl-2(or 3)PyP5+) have been regarded as the most powerful SOD mimics/antioxidants. During dismutation process they reduce and oxidize O2.- with identical rate constants, equally well accepting and donating electrons. They further readily oxidize ascorbate and glutathione and reduce oxygen. Given the abundance of O2 and cellular reductants, MnPs may act in vivo as pro-oxidants - catalysts of ascorbate-driven O2 reduction to O2. /H2O2. To support such “opposing” line of thoughts we explored a very simple and straightforward superoxide-specific SOD-deficient E. coli system, where cationic MnPs act as powerful SOD mimics. Yet, if ascorbate is added to the medium SOD mimics become oxidants, causing oxidative damage to both wild and SOD-deficient strains and disabling their growth. Ascorbate itself imposes no damage. We have previously observed that MnTE-2-PyP5+ alone suppresses oxidative stress in a 4T1 breast cancer mouse model. Yet, if co-administered with ascorbate, its equally potent analogue MnTnHex-2-PyP5+ increases tumor oxidative burden in the same model. Further, MnP/ascorbate system acts as pro-oxidant in five cancer cell lines. Importantly, upon reduction with ascorbate, cationic MnPs lose single charge on metal site which increases their lipophilicity up to 3 orders of magnitude and in turn their bioavailibility. Emerging experimental evidence, thus, suggests that indeed the beneficial effects of Mn porphyrin-based SOD mimics may be exerted via pro-oxidative action also. Upon increased MnP- catalyzed production of peroxide either with exogenous or endogenous ascorbate, cell would react with adaptive response by upregulation of endogenous antioxidative defenses ; final outcome may appear as anti-oxidative action of MnPs. E. coli system, also, reacts via adaptive response and recover time-dependently after initial oxidative attack. The type of action (anti- or pro-oxidative) will depend upon the cellular levels of reactive species, endogenous antioxidants and ratio of SOD and peroxide-removing systems. Such data ask for further exploration of the nature of the therapeutic effects of synthetic SOD mimics in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivan Kos (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Ines Batinić-Haberle (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Benov, Ludmil; Kos, Ivan; Tovmasyan, Artak; Batinic-Haberle, Ines
Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo // Free Radical Biology & Medicine / Kelvin J. A. Davis (ur.).
Orlando, USA: Elsevier, 2010. str. S194-S194 (poster, međunarodna recenzija, sažetak, znanstveni)
Rajić, Z., Benov, L., Kos, I., Tovmasyan, A. & Batinic-Haberle, I. (2010) Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo. U: Kelvin J. A. Davis (ur.)Free Radical Biology & Medicine.
@article{article, year = {2010}, pages = {S194-S194}, keywords = {Mn porphyrins, ascorbic acid, SOD mimics, antioxidant, pro-oxidant}, title = {Cationic Mn porphyrins change their action from anti- to pro-oxidative in the presence of cellular reductants. Relevance to understanding beneficial therapeutic effects of SOD mimics in vivo}, keyword = {Mn porphyrins, ascorbic acid, SOD mimics, antioxidant, pro-oxidant}, publisher = {Elsevier}, publisherplace = {Orlando, USA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font