engleski

Natural killer cells in oral lichen ruber

NK-cells are one of main indicators of nonspecific and innate immunity. disorder of NK-cell functional activity can result with autoimmune diseases and it can suppose that every disorder has significant role in pathogenetic mechanisms in OLR, like oral mucocutaneous autoimmunity disease. Result of NK-cells function, like indicator of innate immunity condition, can be very interesting in patients with OLR. Examination of NK-cell functional activity and their total count in peripheral blood of patients were spended, which included 38 patients. Examination of total NK-cells count in periphertal blood and their activity spended by method described by Rabatic et al. Result showed statistically significant correlation with control groups in all functional activity, NK-cell to target cells, in ratio 25:1, 50:1, 100:1 (E:T)%l.Statistically significant result lower NK-cells functional activity, and total NK-cell count in peripheral blood patients with this recurrent oral disease. That disorder can have important role in pathogenetic mechanisms in beginnings of OLR.

innate immunity; NK-cells; oral lichen ruber

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