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Pregled bibliografske jedinice broj: 491376

Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo


Babić, Marina; Pyzik, Michal; Zafirova, Biljana; Mitrović, Maja; Butorac, Višnja; Lanier, Lewis L.; Krmpotić, Astrid; Vidal, Silvia M.; Jonjić, Stipan.
Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo // The Journal of experimental medicine, 207 (2010), 12; 2663-2673 doi:10.1084/jem.20100921 (međunarodna recenzija, članak, znanstveni)


Naslov
Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo

Autori
Babić, Marina ; Pyzik, Michal ; Zafirova, Biljana ; Mitrović, Maja ; Butorac, Višnja ; Lanier, Lewis L. ; Krmpotić, Astrid ; Vidal, Silvia M. ; Jonjić, Stipan.

Izvornik
The Journal of experimental medicine (0022-1007) 207 (2010), 12; 2663-2673

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MCMV; MHC-I; NK cells; Ly49 receptors;

Sažetak
Cytomegaloviruses (CMVs) are renowned for interfering with the immune system of their hosts. To sidestep antigen presentation and destruction by CD8+ T cells, these viruses reduce expression of major histocompatibility complex class I (MHC I) molecules. However, this process sensitizes the virus-infected cells to natural killer (NK) cell–mediated killing via the “missing self” axis. Mouse cytomegalovirus (MCMV) uses m152 and m06 encoded proteins to inhibit surface expression of MHC I molecules. In addition, it encodes another protein, m04, which forms complexes with MHC I and escorts them to the cell surface. This mechanism is believed to prevent NK cell activation and killing by restoring the “self” signature and allowing the engagement of inhibitory Ly49 receptors on NK cells. Here we show that MCMV lacking m04 was attenuated in an NK cell– and MHC I–dependent manner. NK cell–mediated control of the infection was dependent on the presence of NK cell subsets expressing different inhibitory Ly49 receptors. In addition to providing evidence for immunoevasion strategies used by CMVs to avoid NK cell control via the missing-self pathway, our study is the first to demonstrate that missing self–dependent NK cell activation is biologically relevant in the protection against viral infection in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Rad je kao predavanje prezemntiran na skupu 2010 Annual Meeting of the Croatian Immunological Society, održanom od 23.-26.09.2010., Mali Lošinj, Hrvatska ; objavljen u Knjizi sažetaka.



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Babić, Marina; Pyzik, Michal; Zafirova, Biljana; Mitrović, Maja; Butorac, Višnja; Lanier, Lewis L.; Krmpotić, Astrid; Vidal, Silvia M.; Jonjić, Stipan.
Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo // The Journal of experimental medicine, 207 (2010), 12; 2663-2673 doi:10.1084/jem.20100921 (međunarodna recenzija, članak, znanstveni)
Babić, M., Pyzik, M., Zafirova, B., Mitrović, M., Butorac, V., Lanier, L., Krmpotić, A., Vidal, S. & Jonjić, S. (2010) Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo. The Journal of experimental medicine, 207 (12), 2663-2673 doi:10.1084/jem.20100921.
@article{article, year = {2010}, pages = {2663-2673}, DOI = {10.1084/jem.20100921}, keywords = {MCMV, MHC-I, NK cells, Ly49 receptors, }, journal = {The Journal of experimental medicine}, doi = {10.1084/jem.20100921}, volume = {207}, number = {12}, issn = {0022-1007}, title = {Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo}, keyword = {MCMV, MHC-I, NK cells, Ly49 receptors, } }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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