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Pregled bibliografske jedinice broj: 491038

TP53 gene polymorphisms and breast cancer in Croatian women: a pilot study


Bišof, Vesna; Peričić Salihović, Marijana; Smolej Narančić, Nina; Škarić-Jurić, Tatjana; Jakić-Razumović, Jasminka; Janićijević, Branka; Turek, Stjepan; Rudan, Pavao
TP53 gene polymorphisms and breast cancer in Croatian women: a pilot study // European journal of gynaecological oncology, 31 (2010), 5; 539-544 (međunarodna recenzija, članak, znanstveni)


Naslov
TP53 gene polymorphisms and breast cancer in Croatian women: a pilot study

Autori
Bišof, Vesna ; Peričić Salihović, Marijana ; Smolej Narančić, Nina ; Škarić-Jurić, Tatjana ; Jakić-Razumović, Jasminka ; Janićijević, Branka ; Turek, Stjepan ; Rudan, Pavao

Izvornik
European journal of gynaecological oncology (0392-2936) 31 (2010), 5; 539-544

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Breast cancer; polymorphism; TP53 gene; Croatia

Sažetak
A case-control retrospective association study was conducted to investigate a possible association of the TP53 polymorphisms, Arg72Pro and PIN3 (+16bp), with sporadic breast cancer in Croatian women. Ninety-five women with breast cancer and 108 age-matched healthy women were analyzed. Arg72Pro polymorphism was detected by TaqMan essay. For designation of PIN3 (+16bp) polymorphism DNA amplification was performed by the polymerase chain reaction (PCR) while the PCR products were detected by capillary electrophoresis. Homozygous genotype of minor allele of the PIN3 (+16bp) polymorphism was associated with sporadic breast cancer (OR=2.15, 95% confidence interval [CI] 1.80-2.56, p=0.006). For Arg72 polymorphism, the odds ratio for breast cancer of ArgPro versus reference genotype ArgArg was 0.55 (95% CI 0.30-1.02, p=0.039) suggesting the protective effect. Although different haplotypes did not influence the susceptibility to the disease, the joint occurrence of genotype combination ProPro/A2A2 frequent in cases, was associated with sporadic breast cancer (OR=2.20, 95% CI 1.89-2.56, p=0.021). The study provides evidence of the association of the TP53 gene Arg72Pro and PIN3 (+16bp) polymorphisms with sporadic breast cancer in the Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Etnologija i antropologija



POVEZANOST RADA


Projekt / tema
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Pavao Rudan, )
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Branka Janićijević, )

Ustanove
Institut za antropologiju,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Scisearch, Research Alert, Current Advances in Cancer Research