engleski

RESULTS OF A CROATIAN PROSPECTIVE STUDY ON TRANSPLACENTAL GENOTOXICITY OF ANTIPELIPETIC DRUGS

Antiepileptic therapy is signifi cant medical challenge due to interindividual diff erences in type and aetiology of epilepsy combined with interindividual diff erences in metabolism of antiepileptic drugs (AED). Success of AED today, is also measured by their side eff ects, which in some cases, such as their transplacental genotoxicity and impact on fetal development, have to be prevented. In majority of cases antiepileptic drugs are aromatase inhibitors. Some of them are described as potential teratogenic agents. Genome damage caused by antiepileptic drugs may be a consequece of their direct clastogenic or methylating eff ect on DNA. Target organs for genotoxic effects may be diff erent in the mother and the foetus due to specifi c stage of developmental physiology and enzyme distribution and consequently diff erent metabolic pathways in the foetus and the mother, causing diff erent levels of genome damage in the mother and the foetus.

antiepileptic drugs (AED); epilepsy; pregnancy; genome damage

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