engleski

CAROTID STIFFNESS IN MIGRAINE

Recently migraine was associated with increased arterial stiff ness and with risk for brain white matter lesions (WML) and stroke, especially in migraineurs with aura (MA). Th e aim of this study was to explore beta stiff ness index (BSI), the most relevant clinical stiff ness parameter, in migraneurs compared to age matched controls. T-test was used for statistical analysis. Fifty-fi ve patients were examined (45 women), and mathched with 45 controls with no history of headache (30 women). Subjects and controls were normotensive (123±12 over 79±10 mmHg and 117±8 over75 ±7 mmHg) and had normal BMI (25, 04±4, 06 kg/m2 and 23, 71±2, 71 kg/m2). In 7 migraneurs migraine onset was belated (after 40 yrs). In all patients genetic analysis revealed heterozygous or homozygous mutation in MTHFR (35 pts and 8 pts with MA), PAI-1 (35 pts and 6 pts with MA) and ACE converase gene (30 pts and 10 pts with MA). Four pts had a single mutation, 10 had two mutations, 2 pts had all three mutations and were lesion free on CT scan, and 4 were without analysis. CT and MRI brain scans showed WML in 11 pts, 4 in MA pts. Average BSI was 7, 80±8, 71 (right CCA) and 8, 00±11, 15 (left CCA) in migraneurs while in controls 5, 56±3, 63 (right CCA) and 5, 64±4, 77 (left CCA) (p<0, 05). In conclusion, we noted increased carotid BSI in migraineurs and increase in mutation of coagulation regulation genes. We believe that pts having both and MA should be more often monitored due to greater chance of future stroke occurrence.

carotid artery; migraine; stroke

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