engleski

Quantitative analysis of blood flow in the estimation of renal transplant function

We performed 74 perfusion studies of renal transplants in 52 patients using Tc99m- pertechnetate. Renal blood flow (RBF) was expressed as a percentage of cardiac output (CO). mean RBF/CO in patients with creatinine serum levels (CSL) <150 umol/l was 13.1% +/- 5.6, and for those who had CSL between 150 and 300 umol/l was 8.1% +/- 3.8. Patients with CSL between 301 and 450 umol/l had mean RBF/CO 5.6% +/- 2.5 and those with CSL > 450 umol/l had mean RBF/CO 3.6% +/- 1.1. Differences among all groups and a correlation between CSL and RBF/CO values were statistically significant. Patients with chronic rejection on biopsy had higher RBF/CO values (mean 5.3% +/- 2.4) than those with acute rejection (mean 3.9% +/- 0.2) and cyclosporin nephrotoxicity (mean 3.8% +/- 1.6) RBF/CO values are accurate in differentiation of renal transplants regarding their function and they could be helpful in the estimation of transplant function alteration.

kidney transplantation; renal circulation; blood floow velocity

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